347420
β-Glucuronidase, Helix pomatia
Native β-glucuronidase from Helix pomatia. Useful for hydrolyzing urinary steroid conjugates prior to steriod assays. Note: 1 MU = 1,000,000 units.
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Productos recomendados
origen biológico
Helix pomatia
Nivel de calidad
descripción
Merck USA index - 14, 4466
Formulario
liquid
fabricante / nombre comercial
Calbiochem®
condiciones de almacenamiento
do not freeze
solubilidad
aqueous buffer: soluble
actividad extraña
Aryl sulfatase ≤2%
Condiciones de envío
wet ice
temp. de almacenamiento
2-8°C
Categorías relacionadas
Descripción general
Native β-glucuronidase from Helix pomatia. Useful for hydrolyzing urinary steroid conjugates prior to steriod assays. Note: 1 MU = 1,000,000 units.
Native β-glucuronidase from Helix pomatia. Useful for hydrolyzing urinary steroid conjugates prior to steriod assays. Note: 1 MU = 1,000,000 units.
Acciones bioquímicas o fisiológicas
β-Glucuronidase, a member of the 2 glycosyl hydrolase family, is involved in the hydrolysis of β-glucuronic acid residues from the non-reducing termini of glycosaminoglycans (GAGs).[1] β-Glucuronidase catalyzes the complete hydrolysis of urinary conjugates.[2] β-Glucuronidase serves as a possible candidate enzyme for gene-mediated enzyme prodrug therapy for glucuronide prodrugs.[3] β-glucuronidase-responsive albumin binding prodrugs might be an effective therapeutic practice for treating solid tumors.[4]
Advertencia
Toxicity: Standard Handling (A)
Definición de unidad
One unit is defined as the amount of enzyme that will liberate 1.0 µg phenolphthalein from phenolphthalein glucuronide per h at 37°C, pH 5.0.
Forma física
A 65% saturated ammonium sulfate suspension.
Reconstitución
Following reconstitution, store in refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
Otras notas
Shibasaki, H., et al. 2001. Steroids66, 795.
Graef, V., et al. 1977. Clin. Chem.23, 532.
Graef, V., et al. 1977. Clin. Chem.23, 532.
Información legal
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Resp. Sens. 1 - Skin Sens. 1
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
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Isabelle Tranoy-Opalinski et al.
European journal of medicinal chemistry, 74, 302-313 (2014-02-01)
The design of novel antitumor agents allowing the destruction of malignant cells while sparing healthy tissues is one of the major challenges in medicinal chemistry. In this context, the use of non-toxic prodrugs programmed to be selectively activated by beta-glucuronidase
K-C Chen et al.
Cancer gene therapy, 14(2), 187-200 (2006-09-16)
Gene-mediated enzyme prodrug therapy (GDEPT) seeks to increase the therapeutic index of anti-neoplastic agents by promoting selective activation of relatively nontoxic drug derivatives at sites of specific enzyme expression. Glucuronide prodrugs are attractive for GDEPT due to their low toxicity
Prabha Dwivedi et al.
Chemosphere, 199, 256-262 (2018-02-16)
Human exposure to consumer and personal care products chemicals such as phenols, including parabens and other antimicrobial agents, can be assessed through biomonitoring by quantifying urinary concentrations of the parent chemical or its metabolites, often after hydrolysis of phase II
Loganathan Arul et al.
Bioinformation, 2(8), 339-343 (2008-08-08)
Glycosyl hydrolases hydrolyze the glycosidic bond either in carbohydrates or between carbohydrate and non-carbohydrate moiety. The beta-glucuronidase (beta D-glucuronoside glucuronosohydrolase; EC 3.2.1.31) enzyme belongs to the family-2 glycosyl hydrolase. The E. coli borne beta-glucuronidase gene (uidA) was devised as a
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