118415

ADP-HPD, Dihydrate, Ammonium Salt

≥95% (HPLC), lyophilized solid, PARG inhibitor, Calbiochem^®

• Sinónimos: ADP-HPD, Dihydrate, Ammonium Salt, Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
• Fórmula empírica (notación de Hill): C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
• Peso molecular: 595.39
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: ADP-HPD, Dihydrate, Ammonium Salt, ADP-HPD, Dihydrate is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC₅₀ = 120 nM).
• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: lyophilized solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubilidad: water: 5 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC₅₀ = 120 nM) vs. ADP-ribose (IC₅₀ = 120 mM). Also inhibits NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC₅₀ = 260 µM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration.

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC₅₀ = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC₅₀ = 260 µM). Note: 1 set = 5 x 60 µg.

Note: 1 set = 5 x 60 µg

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
PARG

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 120 nM against poly(ADP-ribose) glycohydrolase (PARG)

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.

Otras notas

Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 9886.
Slama, J.T., et al. 1995. J. Med. Chem.38, 389.
Slama, J.T., et al. 1995. J. Med. Chem.38, 4332.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable