Regarding KITALYSIS-CN-1KT KitAlysis™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4, there are links to specific usage instructions posted on this page.
https://www.sigmaaldrich.com/product/aldrich/kitalysiscn#product-documentation
These describe reactions carried out at various temperatures (depending on the substrate used), e.g. 60 - 80 degrees C, controlled by the use of a heating bath.
KITALYSIS-CN
KitAlysis™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4
Sinónimos:
Amination Screening Kit, Buchwald-Hartwig Amination
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.22
En este momento no podemos mostrarle ni los precios ni la disponibilidad
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reaction suitability
reaction type: Buchwald-Hartwig Amination
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings
reagent type: catalyst
core: palladium
storage temp.
room temp
General description
The KitAlysis™ High Throughput Buchwald–Hartwig Amination Reaction Screening Kit enables chemists to quickly and efficiently screen Buchwald–Hartwig C–N cross-coupling reaction conditions. Quick identification of optimal conditions allows faster scale-up of the synthetic reaction. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.
Application
There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.
Two Solvents, Weak Base (Cs2CO3)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here
Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains
Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).
Two Solvents, Weak Base (Cs2CO3)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here
Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains
- 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
- 2 bases (NaOt-Bu and Cs2CO3)
- 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
- 2 substrate reaction vials with stir bars
- 1 internal standard
- 4 reaction block replacement films
Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).
Features and Benefits
- Designed and tested by synthetic chemists
- Easily run 24-microscale reaction in parallel
- 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
- Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks
Legal Information
KitAlysis is a trademark of Sigma-Aldrich Co. LLC
Solo componentes del kit
Referencia del producto
Descripción
- SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA
Los componentes del kit también están disponibles por separado
Referencia del producto
Descripción
SDS
- 900634N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mLSDS
- 9006401,4-Dioxane, anhydrous, ZerO2®, 99.8% 8 mLSDS
- 702706Sodium tert-butoxide solution, 2 M in THF, ZerO2® 4 mLSDS
- 747130Josiphos SL-J009-1 Pd G3 5 µmolSDS
- 753009SPhos Pd G2 5 µmolSDS
- 753246RuPhos Pd G2 5 µmolSDS
- 756482P(t-Bu)3 Pd G2 5 µmolSDS
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Referencia del producto
Descripción
Precios
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Referencia del producto
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Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral - STOT SE 3
target_organs
Central nervous system, Kidney,Adrenal gland,Testes, Respiratory system
supp_hazards
Storage Class
4.2 - Pyrophoric and self-heating hazardous materials
flash_point_f
-4.0 °F - closed cup
flash_point_c
-20 °C - closed cup
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Certificados de análisis (COA)
Lot/Batch Number
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High-Throughput Experimentation in Catalysis and Materials Science.
Gordillo A, et al. et al.
Ullmann's Encyclopedia of Industrial Chemistry (2014)
Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Industry.
Schmink JR, et al.
Aldrichimica Acta, 46, 71-80 (2013)
Spencer D Dreher et al.
Journal of the American Chemical Society, 130(29), 9257-9259 (2008-06-28)
Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in
Karl D Collins et al.
Nature chemistry, 6(10), 859-871 (2014-09-23)
New organic reactivity has often been discovered by happenstance. Several recent research efforts have attempted to leverage this to discover new reactions. In this Review, we attempt to unify reported approaches to reaction discovery on the basis of the practical
Protocolos
Protocol for the KitAlysis™ Buchwald-Hartwig Amination Reaction Screening Kit
Protocol for the KitAlysis™ Buchwald-Hartwig Amination Reaction Screening Kit
Protocol for the KitAlysis™ Buchwald-Hartwig Amination Reaction Screening Kit
Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.
Contenido relacionado
Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.
Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.
Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.
Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.
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Good morning Iwould have a question regarding the KitAlysis™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4. Is It possible to work at various temperatures or it's only thinked for the RT?
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