923389

1-((2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)piperidine-4-carboxylic acid

• Sinónimos: Rigid linker for PROTAC^® development
• Fórmula empírica (notación de Hill): C₁₈H₃₀N₂O₅
• Peso molecular: 354.44
• Número MDL: MFCD34602206
• Código UNSPSC: 12352106
• NACRES: NA.22

Propiedades

• Formulario: powder or crystals
• Nivel de calidad: 100
• idoneidad de la reacción: reagent type: linker
• grupo funcional: Boc; carboxylic acid
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C(O)C(CC1)CCN1CC(CC2)OC32CN(C(OC(C)(C)C)=O)C3
• Clave InChI: CVHPZSHLWZEYQS-UHFFFAOYSA-N

Descripción

Aplicación

1-((2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)piperidine-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Otras notas

Protein Degrader Building Blocks

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Información legal

Practum is a registered trademark of Sartorius Lab Instruments GmbH & Co. KG

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable