900847

4-(Fluorosulfonyl)-3-((trimethylsilyl)ethynyl)benzoic acid

≥95%

• Sinónimos: Carboxyl sulfonyl fluoride TMS-alkyne, Probe building block
• Fórmula empírica (notación de Hill): C₁₂H₁₃FO₄SSi
• Número de CAS: 2088828-92-4
• Peso molecular: 300.38
• UNSPSC Code: 12352106
• NACRES: NA.22

Propiedades

• assay: ≥95%
• form: powder or crystals
• storage temp.: −20°C
• SMILES string: OC(C1=CC(C#C[Si](C)(C)C)=C(S(F)(=O)=O)C=C1)=O

Descripción

Application

4-(Fluorosulfonyl)-3-((trimethylsilyl)ethynyl)benzoic acid is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

Technology Spotlight: Trifunctional Probe Building Blocks
Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable