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Merck

259160

Sigma-Aldrich

1,4,8,11-Tetraazacyclotetradecane

98% (GC)

Sinónimos:

Cyclam

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About This Item

Fórmula empírica (notación de Hill):
C10H24N4
Número de CAS:
Peso molecular:
200.32
Beilstein:
111811
Número CE:
Número MDL:
Código UNSPSC:
12352005
ID de la sustancia en PubChem:
NACRES:
NA.22
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Ensayo

98% (GC)

mp

184-186 °C (lit.)

cadena SMILES

C1CNCCNCCCNCCNC1

InChI

1S/C10H24N4/c1-3-11-7-9-13-5-2-6-14-10-8-12-4-1/h11-14H,1-10H2

Clave InChI

MDAXKAUIABOHTD-UHFFFAOYSA-N

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Descripción general

1,4,8,11-Tetraazacyclotetradecane is an azamacrocycle that forms more stable metal complexes as compared to open chain ligands.[1]

Aplicación

1,4,8,11-Tetraazacyclotetradecane (cyclam) can be used as a ligand in the synthesis of:
  • Cyanide-bridged FeIII-CuII complexes.[2]
  • Zinc fenamate complexes [Zn(cyclam)(fen)2] possessing antimicrobial properties, fen = fenamic acid.[3]
  • Zn(II) complexes with flufenamic acid (flu), [Zn(cyclam)(flu)2].[4]
  • Polyoxometalate-metal organic extended framework, for example [{Cu(cyclam)}3(W7O24)].15.5.H2O.[5]

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves


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Luis G Alves et al.
Dalton transactions (Cambridge, England : 2003), 41(47), 14288-14298 (2012-10-09)
Novel Bn(2)Cyclam-based zirconium complexes of the type (Bn(2)Cyclam)Zr(X)(X') (3, X = X' = OPh; 4, X = X' = SPh; 5, X = Cl, X' = O(i)Pr) were synthesized in good yields via metathesis routes involving the reaction of the
Novel Zn (II) complexes with non-steroidal anti-inflammatory ligand, flufenamic acid: Characterization, topoisomerase I inhibition activity, DNA and HSA binding studies.
Smolkova R, et al.
Journal of Inorganic Biochemistry, 177(17), 143-158 (2017)
Jaeheung Cho et al.
Accounts of chemical research, 45(8), 1321-1330 (2012-05-23)
Metalloenzymes activate dioxygen to carry out a variety of biological reactions, including the biotransformation of naturally occurring molecules, oxidative metabolism of xenobiotics, and oxidative phosphorylation. The dioxygen activation at the catalytic sites of the enzymes occurs through several steps, such
Riccardo Ferdani et al.
Dalton transactions (Cambridge, England : 2003), 41(7), 1938-1950 (2011-12-16)
A new class of cross-bridged cyclam-based macrocycles featuring phosphonate pendant groups has been developed. 1,4,8,11-tetraazacyclotetradecane-1,8-di(methanephosphonic acid) (CB-TE2P, 1) and 1,4,8,11-tetraazacyclotetradecane-1-(methanephosphonic acid)-8-(methanecarboxylic acid) (CB-TE1A1P, 2) have been synthesized and have been shown to readily form neutral copper(II) complexes at room temperature
Synthesis, characterization, DNA binding, topoisomerase I inhibition and antimicrobial activity of four novel zinc (II) fenamates.
Smolkova R, et al.
Polyhedron, 141(17), 230-238 (2018)

Artículos

Micro review of reversible addition/fragmentation chain transfer (RAFT) polymerization.

Micro review of reversible addition/fragmentation chain transfer (RAFT) polymerization.

Micro review of reversible addition/fragmentation chain transfer (RAFT) polymerization.

Micro review of reversible addition/fragmentation chain transfer (RAFT) polymerization.

Protocolos

We presents an article featuring procedures that describe polymerization of methyl methacrylate and vinyl acetate homopolymers and a block copolymer as performed by researchers at CSIRO.

We present an article about RAFT, or Reversible Addition/Fragmentation Chain Transfer, which is a form of living radical polymerization.

Polymerization via ATRP procedures demonstrated by Prof. Dave Haddleton's research group at the University of Warwick.

Polymerization via ATRP procedures demonstrated by Prof. Dave Haddleton's research group at the University of Warwick.

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