156361
Hydantoin
98%
Sinónimos:
2,4-Imidazolidinedione, Glycolylurea
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About This Item
Fórmula empírica (notación de Hill):
C3H4N2O2
Número de CAS:
Peso molecular:
100.08
Beilstein/REAXYS Number:
110598
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
En este momento no podemos mostrarle ni los precios ni la disponibilidad
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Quality Level
assay
98%
form
powder
mp
218-220 °C (lit.)
SMILES string
O=C1CNC(=O)N1
InChI
1S/C3H4N2O2/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7)
InChI key
WJRBRSLFGCUECM-UHFFFAOYSA-N
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Application
Reactant for synthesis of:
N-benzyl aplysinopsin analogs as anticancer agents[1]
D-glutamic acid based inhibitors[2]
Antidiabetic chromonyl-2,4-thiazolidinediones[3]
GSK-3β inhibitors with brain permeability[4]
Thiazolidinedione derivatives as 15-PGDH inhibitors[5]
Radio-sensitizing agents[6]
N-benzyl aplysinopsin analogs as anticancer agents[1]
D-glutamic acid based inhibitors[2]
Antidiabetic chromonyl-2,4-thiazolidinediones[3]
GSK-3β inhibitors with brain permeability[4]
Thiazolidinedione derivatives as 15-PGDH inhibitors[5]
Radio-sensitizing agents[6]
The product has been used as a substrate (at 40 °C and pH 9.0) to determine the D-hydantoinase activity in adzuki bean extract.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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A series of novel substituted (Z)-5-((1-benzyl-1H-indol-3-yl)methylene)imidazolidin-2,4-diones (3a-f) and (Z)-5-((1-benzyl-1H-indol-3-yl)methylene)-2-iminothiazolidin-4-ones (3g-o) have been synthesized utilizing microwave irradiation. These analogs were evaluated for in vitro cytotoxicity against a panel of 60 human tumor cell lines. Compound 3i exhibits potent growth inhibition against
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A bifunctional amine/squaramide catalyst promoted direct aldol addition of an hydantoin surrogate to pyridine 2-carbaldehyde N-oxides to afford adducts bearing two vicinal tertiary/quaternary carbons in high diastereo- and enantioselectivity (d.r. up to >20:1; ee up to 98 %) is reported. Acid
Y Thirupathi Reddy et al.
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A series of (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-dione (9a-9m) and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (10a-10i) derivatives that incorporate a variety of aromatic substituents in both the indole and N-benzyl moieties have been synthesized. These analogs were evaluated for their radiosensitization activity against the HT-29 cell line. Three
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Formaldehyde is a well-known contact sensitizer. Formaldehyde releasers are widely used preservatives in skincare products. It has been found that formaldehyde at concentrations allowed by the European Cosmetics Directive can cause allergic contact dermatitis. However, we still lack information on
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