T7750

2-Thiouracile

≥99%, synthetic, powder

• Synonyme(s) : (2-thioxo -2, 3-dihydropyrimidin-4(1H)-one), 2TU, 4-Hydroxy-2-mercaptopyrimidine
• Formule empirique (notation de Hill) : C₄H₄N₂OS
• Numéro CAS: 141-90-2
• Poids moléculaire : 128.15
• NACRES: NA.51
• PubChem Substance ID: 24900470
• UNSPSC Code: 41106305
• EC Number: 205-508-8
• MDL number: MFCD00006039
• Beilstein/REAXYS Number: 112227
• Assay: ≥99%
• Biological source: synthetic
• Form: powder
• Solubility: 1 M NaOH: 5 mg/mL, clear to very slightly hazy, 1 M NaOH: 50 mg/mL, colorless to faintly yellow

Propriétés

• Nom du produit: 2-Thiouracile, ≥99%
• biological source: synthetic
• Quality Segment: 200
• assay: ≥99%
• form: powder
• mp: >300 °C (lit.)
• solubility: 1 M NaOH: 5 mg/mL, clear to very slightly hazy, 1 M NaOH: 50 mg/mL, colorless to faintly yellow
• SMILES string: O=C1NC(=S)NC=C1
• InChI: 1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
• InChI key: ZEMGGZBWXRYJHK-UHFFFAOYSA-N

Description

General description

2-Thiouracil is a thio-derivative of uracil, a pyrimidine nucleobase.This antithyroid drug has less solubility in H₂O & organic solvents.

Application

2-Thiouracil may be used:

• in the synthesis and characterization of silver colloid and film substrates and their applications in surface-enhanced Raman scattering (SERS)
• to study its electro-oxidation and determination at titanium dioxide (TiO2) nanoparticles-modified gold electrode
• to study the effect of methylation on the deactivation mechanism or the triplet-state dynamics of 2-thiouracil using time-resolved photoelectron spectroscopy

Biochem/physiol Actions

2-Thiouracil acts as an anticancer, antithyroid, and antiviral agent. 2-Thiouracil is a selective melanoma-seeker and competitive inhibitor of neuronal nitric oxide synthase. It also forms complexes with transition metals such as gold (Au), chromium (Cr), zinc (Zn), and silver (Ag).2-thiouracil can be incorporated into the tissue culture medium to inhibit virus replication or movement from infected to healthy tissues during chemotherapy.

Informations sur la sécurité

• pictograms: GHS08
• signalword: Warning
• hcodes: H351
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 2
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges