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Key Documents

SRP8017

Sigma-Aldrich

Progranulin rat

recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE)

Synonyme(s) :

PEPI, Proepithelin

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About This Item

Numéro CAS:
139316-59-9
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

rat

Produit recombinant

expressed in HEK 293 cells

Étiquette/Marqueur

FLAG® tagged

Pureté

>95% (SDS-PAGE)

Forme

lyophilized

Poids mol.

~65 kDa by SDS-PAGE

Conditionnement

pkg of 10 μg

Fabricant/nom de marque

Sigma-Aldrich

Conditions de stockage

avoid repeated freeze/thaw cycles

Impuretés

<0.1 EU/μg endotoxin, tested

Couleur

white

Numéro d'accès UniProt

P23785

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

rat ... Grn(29143)

Description générale

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Forme physique

Lyophilized from 0.2 μm-filtered solution in PBS.

Reconstitution

Reconstitute with 100 μL deionized water.

Autres remarques

Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG®-tag.

Informations légales

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Lorenz Thurner et al.
Digestive diseases and sciences, 59(8), 1733-1742 (2014-03-05)
Recently, we identified neutralizing autoantibodies against progranulin (PGRN) in a wide spectrum of rheumatic diseases including cases with enteropathic spondylarthritis. PGRN is a secreted protein with strong anti-inflammatory effects, believed to be mediated by the direct inhibition of TNF receptors
Masato Kanazawa et al.
Brain : a journal of neurology, 138(Pt 7), 1932-1948 (2015-04-04)
In the central nervous system, progranulin, a glycoprotein growth factor, plays a crucial role in maintaining physiological functions, and progranulin gene mutations cause TAR DNA-binding protein-43-positive frontotemporal lobar degeneration. Although several studies have reported that progranulin plays a protective role
Michael J Smout et al.
PLoS pathogens, 11(10), e1005209-e1005209 (2015-10-21)
Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury

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