SML0198

Fenoldopam mesylate

≥98% (HPLC)

• Synonyme(s) : Fenoldopam methanesulfonate
• Formule empirique (notation de Hill): C₁₆H₁₆ClNO₃ · CH₄O₃S
• Numéro CAS: 67227-57-0
• Poids moléculaire : 401.86
• Numéro CE : 266-612-7
• Numéro MDL: MFCD04112986
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825223
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to tan
• Pf: 271 °C (lit.)
• Solubilité: DMSO: ≥15 mg/mL at ~60 °C
• Température de stockage: room temp
• Chaîne SMILES: CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23
• InChI: 1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)
• Clé InChI: CVKUMNRCIJMVAR-UHFFFAOYSA-N
• Informations sur le gène: human ... DRD1(1812)

Description

Application

Fenoldopam mesylate may be used to study dopamine D₁-mediated cell signaling.

Actions biochimiques/physiologiques

Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.

Fenoldopam mesylate is a selective dopamine D₁ receptor agonist used as an antihypertensive agent. It is an agonist for D₁-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D₂-like receptors, α1 and α-adrenoceptors, 5HT₁ and 5HT₂ receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.

Caractéristiques et avantages

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H317,H319
• Conseils de prudence: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable