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SAB5500001

Sigma-Aldrich

Anti-beta-Actin antibody, Rabbit monoclonal

clone SP124, recombinant, expressed in proprietary host, affinity isolated antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Produit recombinant

expressed in proprietary host

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

SP124, monoclonal

Espèces réactives

human (tested)

Réactivité de l'espèce (prédite par homologie)

chicken, mouse, rat, bovine, rabbit, pig, dog, hamster, frog

Technique(s)

flow cytometry: 1:100
immunoblotting: 1:200
immunohistochemistry: 1:200

Isotype

IgG

Numéro d'accès UniProt

P60709

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ACTB(60)

Description générale

ACTB (actin β) gene codes for β-actin. It is a cytoskeletal housekeeping protein. It is present in the cytoplasm. This gene is located on human chromosome 7p22.1.
Beta-actin is a nonmuscle cytoskeletal protein in all human cell types and is involved in cell motility, structure, and integrity. There are six different actin isoforms in human. Antibody to beta-actin provides a specific and useful tool in studying the intracellular distribution of beta-actin and the static and dynamic aspects of the cytoskeleton.

Immunogène

Synthetic peptide near the N-terminus of human beta-Actin protein.

Application

Anti-Actin-Beta antibody has been used in western blotting.

Actions biochimiques/physiologiques

β-Actin modulates cell growth, migration and the G-actin pool. Mutations in ACTB leads to pleiotropic developmental disorder.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Guo Ying et al.
Molecular medicine reports, 12(5), 7491-7495 (2015-10-16)
The present study aimed to investigate the expression status and clinical implications of DEK in breast cancer, in order to contribute to developments in breast cancer management. DEK expression status was detected in 628 breast cancer specimens by western blot
Exosomes Derived from Squamous Head and Neck Cancer Promote Cell Survival after Ionizing Radiation
Mutschelknaus L, et al.
PLoS ONE (2016)
Nicotinic ?7 receptor inhibits the acylation stimulating protein?induced production of monocyte chemoattractant protein?1 and keratinocyte?derived chemokine in adipocytes by modulating the p38 kinase and nuclear factor??B signaling pathways
Jiao ZY, et al.
Molecular Medicine Reports, 14(4), 2959-2966 (2016)
Soy isoflavones protect against H2O2-induced injury in human umbilical vein endothelial cells
Jin L, et al.
Molecular Medicine Reports, 12, 4476-4482 (2015)
Xian-Lu Song et al.
Journal of Cancer, 8(13), 2501-2510 (2017-09-14)
miRNAs play critical role in the development and progression of prostate cancer. Here we studied the role of miR-618 in prostate cancer migration and invasion. miR-618 was downregulated in metastatic androgen-independent prostate cancer (AIPC), patients with low miR-618 had poor
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