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Key Documents

SAB1305554

Sigma-Aldrich

MONOCLONAL ANTI-BETA-ACTIN antibody produced in mouse

clone 137CT26.1.1, IgG fraction of antiserum, buffered aqueous solution

Synonyme(s) :

ACTB, Actin, cytoplasmic 1, Actin, cytoplasmic 1, N-terminally processed, Beta-actin

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

137CT26.1.1, monoclonal

Forme

buffered aqueous solution

Poids mol.

41737 Da

Espèces réactives

mouse, human

Technique(s)

immunofluorescence: 1:10-1:50
immunohistochemistry: 1:25
western blot: 1:1000

Isotype

IgG1κ

Numéro d'accès NCBI

NP_001092.1

Numéro d'accès UniProt

P60709

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ACTB(60)

Description générale

β-actin (ACTB), a member of the actin multigene family, is an isoform of actin-associated with non-muscle cells. ACTB is a housekeeping gene mapped to human chromosome 7p22.1.

Application

Monoclonal Anti-Beta-Actin antibody produced in mouse has been used in western blotting at a dilution of 1:1000.

Actions biochimiques/physiologiques

β-actin (ACTB) forms the core of the cell cytoskeleton. The polymerization of β-actin is essential for cell physiology. It may serve as a potential chemotherapeutic agent. Mutation in the ACTB gene is implicated in sensory hearing loss, delayed-onset generalized dystonia and a combination of ventral midline malformations. A loss-of-function mutation in the ACTB gene may cause intellectual disability.

Forme physique

Supplied in PBS with 0.09% (W/V) sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Sequence and structural analysis of beta-actin protein of fishes, using bioinformatics tools and techniques
Acharya UR, et al.
International journal of biosciences, 4(11) (2014)
Immacolata Andolfo et al.
Blood advances, 7(12), 2681-2693 (2023-01-04)
Gain-of-function mutations in PIEZO1 cause dehydrated hereditary stomatocytosis (DHS) or hereditary xerocytosis, an autosomal dominant hemolytic anemia characterized by high reticulocyte count, a tendency to macrocytosis, and mild jaundice, as well as by other variably penetrant clinical features, such as
Gaëlle Rached et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(6), e2204846-e2204846 (2023-01-17)
Insulin release is tightly controlled by glucose-stimulated calcium (GSCa) through hitherto equivocal pathways. This study investigates TRPC3, a non-selective cation channel, as a critical regulator of insulin secretion and glucose control. TRPC3's involvement in glucose-stimulated insulin secretion (GSIS) is studied
Induction of drug resistance in human hepatoma cells cultured on a silicate fiber based 3d scaffold
Mizutami T, et al.
Advances in Biochemical Engineering null
Sara Cuvertino et al.
American journal of human genetics, 101(6), 1021-1033 (2017-12-09)
ACTB encodes β-actin, an abundant cytoskeletal housekeeping protein. In humans, postulated gain-of-function missense mutations cause Baraitser-Winter syndrome (BRWS), characterized by intellectual disability, cortical malformations, coloboma, sensorineural deafness, and typical facial features. To date, the consequences of loss-of-function ACTB mutations have
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