SAB3500209
Anti-AGTR1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonyme(s) :
Anti-AT1, Anti-AT1R, Anti-Ang II, Anti-Angiotensin II receptor type 1
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About This Item
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Espèces réactives
rat, human, mouse
Technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... AGTR1(185)
Description générale
Angiotensin II receptor, type 1 (AGTR1) is a G-protein coupled receptor possessing seven transmembrane functional domains. AGTR1 gene spanning around 45.1kb, with five exons, is located on human chromosome 3q21−q25. AGTR1 is highly expressed on endothelial cells, monocytes, podocytes, renal vascular smooth muscle cells and renal arteries.
Angiotensin II receptor, type 1 or AT1 receptor (AGRR1, AT1R) is a receptor for the vasoconstriction peptide angiotensin II involved in the regulation of cardiovascular effects such as blood vasoconstriction (blood pressure), aldosterone and vasopressin secretion, cardiac hypertrophy, vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation.
Rabbit polyclonal anti-AGTR1 reacts with mouse, human, and rat angiotensin II receptor.
Immunogène
AGTR1 antibody was raised against a 16 amino acid peptide from near the center of human AGTR1.
Application
Anti-AGTR1 antibody produced in rabbit has been used in in situ proximity ligation assay (PLA) and immunoblotting.
Rabbit polyclonal anti-AGTR1 is used to tag angiotensin II receptor for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of angiotensin II receptor in the regulation of processes that affect vascular functions such as blood pressure and blood flow.
Actions biochimiques/physiologiques
Angiotensin II receptor, type 1 (AGTR1) has a key function in vascular smooth muscle contraction and maintenance of vasopressor effects by controlling aldosterone secretion. The binding of angiotensin II to AGTR1 contributes to the proliferation of vascular smooth muscle cells by the activation of G protein. The binding also results in the activation of Ca2+ dependent kinases as IP3 (inositol triphosphate) and MAPK (mitogen-activated protein kinases) for the synthesis of proteins and expression of proto-oncogenes, respectively. AGTR1 is associated with high risk of hypertension and cardiovascular diseases.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Liaison
The action of this antibody can be blocked using blocking peptide SBP3500209.
Forme physique
Supplied in PBS with 0.02% sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Lipid rafts are required for signal transduction by angiotensin II receptor type 1 in neonatal glomerular mesangial cells
Adebiyi A, et al.
Experimental Cell Research, 324(1), 92-104 (2014)
Daniel Navin Olschewski et al.
BMC neuroscience, 25(1), 29-29 (2024-06-27)
Astrocytes are the most abundant cell type of the central nervous system and are fundamentally involved in homeostasis, neuroprotection, and synaptic plasticity. This regulatory function of astrocytes on their neighboring cells in the healthy brain is subject of current research.
Hypomethylation of the angiotensin II type I receptor (AGTR1) gene along with environmental factors increases the risk for essential hypertension
Lin J, et al.
Cardiology, 137(2), 126-135 (2017)
Post-Transcriptional Control of Angiotensin II Type 1 Receptor Regulates Osteosarcoma Cell Death
Zhao Y, et al.
Cellular Physiology and Biochemistry, 45(4), 1581-1589 (2018)
Asako Kumagai et al.
Hypertension (Dallas, Tex. : 1979), 78(1), 138-150 (2021-04-13)
[Figure: see text].
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