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N3279

Sigma-Aldrich

Monoclonal Anti-Nerve Growth Factor-β antibody produced in mouse

clone 25623, purified immunoglobulin, lyophilized powder

Synonyme(s) :

Anti-NGF-β

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About This Item

Numéro MDL:
MFCD00282385
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

25623, monoclonal

Forme

lyophilized powder

Espèces réactives

human, rat, mouse

Technique(s)

capture ELISA: 2-8 μg/mL (detection antibody at 0.1-0.4 μg/ml)
neutralization: 0.1-0.4 μg/mL

Impuretés

endotoxin, tested

Isotype

IgG1

Numéro d'accès UniProt

P01138

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NGF(4803)
mouse ... Ngf(18049)

Immunogène

recombinant human NGF-β.

Actions biochimiques/physiologiques

Nerve Growth factor (NGF) is a growth factor that is essential for the development and maintenance of the nervous system. NGF is composed of three non-covalently linked α, β and γ subunits. The β subunit is responsible for the biological functions of NGF. Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGF is important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. NGF is also implicated in inflammation and allergic reactions.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Notes préparatoires

Purified using Protein G.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Josemberg S Baptista et al.
PloS one, 15(1), e0228155-e0228155 (2020-01-28)
Intervertebral disc (IVD) degeneration is a remodeling process mediated by several growth factors and cytokines. This process has been extensively studied in vitro and with pathologic specimens obtained during surgery for scoliosis or back pain. However, the occurrence and temporal
Seong Hoon Seo et al.
The Journal of investigative dermatology, 140(11), 2199-2209 (2020-04-06)
Itch in atopic dermatitis (AD) is aggravated under warm conditions. Transient receptor potential vanilloid (TRPV) 3, a member of the thermosensitive transient receptor potential channels, is activated by innocuous heat and is abundantly expressed in keratinocytes. The potential role of
Wolfgang Andreas Nockher et al.
The Journal of allergy and clinical immunology, 117(3), 583-589 (2006-03-09)
Understanding the complex pathophysiology of allergic diseases has been a main challenge of clinical and experimental research for many years. It is well known that the allergic inflammation triggers neuronal dysfunction and structural changes in the diseased tissues such as
C D Mills et al.
European journal of pain (London, England), 17(4), 469-479 (2012-08-24)
Injection of nerve growth factor (NGF) produces mechanical and thermal hypersensitivity in rodents and humans. Treatment with sequestering antibodies demonstrates the importance of NGF in various pain states, with efficacy seen in a number of animal pain models and in
Y Indo
Clinical genetics, 82(4), 341-350 (2012-08-14)
Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder characterized by insensitivity to pain, anhidrosis (the inability to sweat) and mental retardation. Nerve growth factor (NGF) is a well-known neurotrophic factor essential for the survival and
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