N2280
Monoclonal Anti-Nitric Oxide Synthase, Brain (1-181) antibody produced in mouse
clone NOS-B1, ascites fluid
Synonyme(s) :
Anti-bNOS
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About This Item
Produits recommandés
Source biologique
mouse
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
ascites fluid
Type de produit anticorps
primary antibodies
Clone
NOS-B1, monoclonal
Poids mol.
antigen 150-160 kDa
Contient
15 mM sodium azide
Espèces réactives
rat, goat, pig, human
Technique(s)
microarray: suitable
western blot: 1:3,000 using fresh rat cerebellum extract
Isotype
IgG1
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... NOS1(4842)
rat ... Nos1(24598)
Description générale
Monoclonal Anti-Nitric Oxide Synthase-Brain (bNOS) (mouse IgG1 isotype) is derived from the NOS-B1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Nitric oxide synthase (NOS) has been localized in many different cell types. Type I NOS is found in neurons. It is a 150-160 kDa protein, also called NOS-1, neuronal NOS (nNOS), brain NOS (bNOS), cerebral NOS, constitutive NOS or Ca2+- regulated NOS (cNOS). bNOS is present also in skeletal muscle, where it is complexed with dystrophin, and is absent in Duchenne′s muscular dystrophy, which perhaps accounts for symptoms of the disease.
Spécificité
Monoclonal Anti-Nitric Oxide Synthase, Brain (1-181) antibody is specific for nitric oxide synthase (NOS) derived from brain (bNOS, 150-160 kDa and several breakdown products of lower M.W.). The product does not bind to NOS derived from macrophages (mNOS) and endothelial cells (eNOS). This antibody is specific for bNOS in humans, goats, pigs and rats.
Immunogène
recombinant neuronal NOS fragment (amino acids 1-181) from rat brain.
Application
Monoclonal Anti-Nitric Oxide Synthase, Brain (1-181) antibody produced in mouse has been used in:
- western blot analysis
- immunocytochemistry
- double immunofluorescence
- immunofluorescence staining
- enzyme-linked immunosorbent assay (ELISA)
- dot blot immunoassay
- immunohistochemical staining
Actions biochimiques/physiologiques
Nitric oxide synthase is an enzyme that catalyzes the formation of nitric oxide. Nitric oxide is responsible for regulating several biochemical functions such as hemostasis, neurotransmission and vascular injury response . Mutations in nitric oxide synthase gene have been associated with diabetic nephropathy.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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The distribution of nitric oxide synthase in the inferior colliculus of guinea pig
Coote EJ, et al.
Neuroscience, 154(1), 218-225 (2008)
Elevated expression of CAPON and neuronal nitric oxide synthase in the sciatic nerve of rats following constriction injury
Cui Z, et al.
The Veterinary Journal, 187(3), 374-380 (2011)
The complex contribution of NOS interneurons in the physiology of cerebrovascular regulation
Duchemin S, et al.
Frontiers in Neural Circuits, 6 (2012)
R C Rogers et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 285(2), R479-R489 (2003-04-26)
Activation of esophageal mechanosensors excites neurons in and near the central nucleus of the solitary tract (NSTc). In turn, NSTc neurons coordinate the relaxation of the stomach [i.e., the receptive relaxation reflex (RRR)] by modulating the output of vagal efferent
K Ashutosh
Current opinion in pulmonary medicine, 6(1), 21-25 (1999-12-23)
Nitric oxide (NO) is synthesized from the amino acid arginine by enzymes called nitric oxide synthases. NO has an important physiologic role in the regulation of vascular tone, response to vascular injury, and hemostasis. It also acts as a neurotransmitter
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