N1790

Naftifine hydrochloride

• Synonyme(s) : Naftifine HCL
• Formule empirique (notation de Hill): C₂₁H₂₁N · HCl
• Numéro CAS: 65473-14-5
• Poids moléculaire : 323.86
• Numéro MDL: MFCD00059047
• Code UNSPSC : 51102829
• ID de substance PubChem : 329818590
• Nomenclature NACRES : NA.76

Propriétés

• Essai: ≥99%
• Niveau de qualité: 200
• Forme: powder
• Solubilité: ethanol: soluble 50 mg/mL
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria; fungi; yeast
• Mode d’action: cell wall synthesis | interferes; enzyme | inhibits
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23
• InChI: 1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
• Clé InChI: OLUNPKFOFGZHRT-YGCVIUNWSA-N

Description

Application

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis[1].

Actions biochimiques/physiologiques

Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion[2]. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells[1].

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable