Accéder au contenu
Merck
Toutes les photos(1)

Principaux documents

Voir toute la documentation

MAK112

Sigma-Aldrich

Arginase Activity Assay Kit

sufficient for 200 colorimetric tests

Synonyme(s) :

Arginase Test Kit

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Code UNSPSC :
12161503
Nomenclature NACRES :
NA.84

Utilisation

sufficient for 200 colorimetric tests

Méthode de détection

colorimetric

Maladie(s) pertinente(s)

cancer; immunological diseases; gastrointestinal diseases

Température de stockage

−20°C

Informations sur le gène

human ... ARG1(383) , ARG2(384)
mouse ... ARG1(11846) , ARG2(11847)
rat ... ARG2(29215) , Arg1(29221)

Description générale

Arginase is a manganese-containing enzyme that catalyzes the conversion of arginine to urea and ornithine. Two isoforms of arginase are present in most mammals which differ in their tissue distribution and subcellular localization. Arginase I is a cytoplasmic protein predominantly expressed in the liver where it catalyzes the fifth and final step of the Urea Cycle. Arginase II is a mitochondrial protein with broader tissue distribution whose function may include nitric oxide and polyamine metabolism. Decreased activity or expression of Arginase I results in the autosomal recessive disorder hyperarginemia. Increased serum Arginase activity is implicated in hepatic injury and in certain pathological conditions such as cancer. Arginase also participates in multiple inflammatory reactions in the immune system, such as macrophage-mediated cytotoxicity.

Application

Arginase Activity Assay Kit has been used to assess the activity of arginase.

Caractéristiques et avantages

Compatible with high-throughput handling systems.

Adéquation

Suitable for the detection of arginase activity in enzyme preparations, serum, plasma, tissue culture, and similar samples. Suitable for studying the effects of drugs on arginase activity.

Principe

In this assay, arginase catalyzes the conversion of arginine to urea and ornithine. The urea produced specifically reacts with the substrate to generate a colored product, proportional to the arginase activity present.

Pictogrammes

Health hazardCorrosion
GHS08,GHS05

Mention d'avertissement

Danger

Mentions de danger

H290,H314,H360FD,H412

Classification des risques

Aquatic Chronic 3 - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1A

Code de la classe de stockage

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
112CE06A26
112CE06A19
112CE06A26
112CE06A19
112CC08A01

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 3

1 of 3

Aspartate Assay Kit sufficient for 100 colorimetric or fluorometric tests

Sigma-Aldrich

MAK095

Aspartate Assay Kit

IL-10 human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Sigma-Aldrich

SRP3312

IL-10 human

Ammonia Assay Kit sufficient for 200 fluorometric tests

Sigma-Aldrich

MAK310

Ammonia Assay Kit

Razieh Tavakoli Oliaee et al.
Microbial pathogenesis, 126, 368-378 (2018-11-07)
Detection of the mechanism of host/parasite interactions in unresponsive forms of anthroponotic cutaneous leishmaniasis (ACL) caused by Leishmania tropica is helpful for immunotherapy and vaccine development. In the present study, the gene expression of toll-like receptors (TLRs), TNF-α, iNOS and
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
Martina H.
Journal of inherited metabolic disease, 39(3), 331?340-331?340 (2016)
Arginase activity, urea, and hydroxyproline concentration are reduced in keratoconus keratocytes.
Stachon T, et al.
Graefe'S Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 255(1), 91-97 (2017)
Yuxin Shu et al.
Immunology, 160(4), 345-356 (2020-04-21)
Macrophages are particularly abundant and play an important role throughout the tumor progression process, namely, tumor-associated macrophages (TAM) in the tumor microenvironment. TAM can be polarized to disparate functional phenotypes, the M1 and M2 macrophages. M1-like type macrophages are defined
Anti-apoptotic role of spermine against lead and/or gamma irradiation-induced hepatotoxicity in male rats.
Rasha A K, et al.
Environmental Science and Pollution Research International, 24(31), 24272-24283 (2017)
Afficher tous les articles scientifiques apparentés

Contenu apparenté

Multiplex Analysis of Hepatotoxic Biomarkers in Drug-Induced Liver Injury| MILLIPLEX® Assays

See how multiplex assays, such as the Luminex® bead-based multiplex immunoassay MILLIPLEX® Rat Liver Injury Panel, enable researchers to simultaneously measure multiple hepatotoxic biomarkers and cytokines to expand knowledge on drug-induced liver injury processes.

Multiplex Analysis of Hepatotoxic Biomarkers in Drug-Induced Liver Injury| MILLIPLEX® Assays

See how multiplex assays, such as the Luminex® bead-based multiplex immunoassay MILLIPLEX® Rat Liver Injury Panel, enable researchers to simultaneously measure multiple hepatotoxic biomarkers and cytokines to expand knowledge on drug-induced liver injury processes.

Multiplex Analysis of Hepatotoxic Biomarkers in Drug-Induced Liver Injury| MILLIPLEX® Assays

See how multiplex assays, such as the Luminex® bead-based multiplex immunoassay MILLIPLEX® Rat Liver Injury Panel, enable researchers to simultaneously measure multiple hepatotoxic biomarkers and cytokines to expand knowledge on drug-induced liver injury processes.

Multiplex Analysis of Hepatotoxic Biomarkers in Drug-Induced Liver Injury| MILLIPLEX® Assays

See how multiplex assays, such as the Luminex® bead-based multiplex immunoassay MILLIPLEX® Rat Liver Injury Panel, enable researchers to simultaneously measure multiple hepatotoxic biomarkers and cytokines to expand knowledge on drug-induced liver injury processes.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique