L1751

Ethyl linoleate

≥99%

• Synonyme(s) : Linoleic acid ethyl ester
• Formule linéaire : CH₃(CH₂)₃(CH₂CH=CH)₂(CH₂)₇COOC₂H₅
• Numéro CAS: 544-35-4
• Poids moléculaire : 308.50
• Numéro Beilstein : 1727827
• Numéro CE : 208-868-4
• Numéro MDL: MFCD00009535
• Code UNSPSC : 12352211
• ID de substance PubChem : 24896290
• Nomenclature NACRES : NA.25

Propriétés

• Source biologique: plant oil (safflower)
• Niveau de qualité: 200
• Pureté: ≥99%
• Forme: liquid
• Indice de réfraction: n20/D 1.455 (lit.)
• Point d'ébullition: 224 °C/17 mmHg (lit.)
• Densité: 0.876 g/mL at 25 °C (lit.)
• Groupe fonctionnel: ester
• Type de lipide: omega FAs
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCC
• InChI: 1S/C20H36O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22-4-2/h8-9,11-12H,3-7,10,13-19H2,1-2H3/b9-8-,12-11-
• Clé InChI: FMMOOAYVCKXGMF-MURFETPASA-N

Description

Application

• Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride.: This study explores the formulation of a self-microemulsifying drug delivery system (SMEDDS) using ethyl linoleate as a key component to improve the oral bioavailability of berberine hydrochloride. The findings indicate a significant increase in bioavailability, demonstrating the potential of SMEDDS in enhancing the absorption of poorly water-soluble drugs (Zhu et al., 2013).


• Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis.: The research includes the use of ethyl linoleate in the study of liver metabolomics to understand the biochemical effects of alcohol dosing. Ethyl linoleate′s role in nonpolar metabolite profiling provides insights into liver function and the metabolic impacts of alcohol consumption (Loftus et al., 2011).


• Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system.: This article reports on the utilization of ethyl linoleate in a self-microemulsifying drug delivery system to enhance the bioavailability of silymarin. The study shows improved absorption and bioavailability of silymarin, highlighting the effectiveness of ethyl linoleate in drug delivery applications (Wu et al., 2006).

Actions biochimiques/physiologiques

Ethyl linoleate may be used as a reference material in assays that quantify fatty acid ethyl esters (FAEEs) for detection of alcohol abuse. Linoleic acid ethyl ester (Ethyl linoleate) may be used and studied as an acetylcholinesterase (AChE) inhibitor.

Ethyl linoleate solated from Oxalis triangularis inhibits forskolin-induced melanogenesis and tyrosinase activity in mouse B16 melanoma cells . This anti-melanogenic effect is mediated by inhibiting cAMP production.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 235.4 °F - closed cup
• Point d'éclair (°C): 113 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)