Yes, Ganciclovir G2536 can be dissolved in DMSO for in vitro application. Additionally, Ganciclovir is available in SML2346 as a ready-made DMSO solution, which is directly applicable for in vitro application.
G2536
Ganciclovir
≥99% (HPLC), powder, viral DNA elongation inhibitor
Synonyme(s) :
2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one, 9-(1,3-Dihydroxy-2-propoxymethyl)guanine, DHPG
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About This Item
Formule empirique (notation de Hill):
C9H13N5O4
Numéro CAS:
Poids moléculaire :
255.23
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.77
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Produits recommandés
Nom du produit
Ganciclovir, ≥99% (HPLC), powder
Niveau de qualité
Essai
≥99% (HPLC)
Forme
powder
Couleur
white
Solubilité
0.1 M HCl: 10 mg/mL
ε (coefficient d'extinction)
12.0 at 256 nm at 1 mM
Spectre d'activité de l'antibiotique
viruses
Mode d’action
DNA synthesis | interferes
Auteur
Roche
Température de stockage
2-8°C
Chaîne SMILES
NC1=Nc2c(ncn2COC(CO)CO)C(=O)N1
InChI
1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
Clé InChI
IRSCQMHQWWYFCW-UHFFFAOYSA-N
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Description générale
Chemical structure: nucleoside
Application
Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required.
Actions biochimiques/physiologiques
Ganciclovir is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research.
Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell.[1] The cell cycle is irreversibly arrested at the G2-M checkpoint.[2] Gap junction involvement in the ganciclovir bystander effect has been studied.[3] Ganciclovir has been used to study loss of telomeres[4] and to evaluate sensitivity of viruses to antiviral treatments.[5]
Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell.[1] The cell cycle is irreversibly arrested at the G2-M checkpoint.[2] Gap junction involvement in the ganciclovir bystander effect has been studied.[3] Ganciclovir has been used to study loss of telomeres[4] and to evaluate sensitivity of viruses to antiviral treatments.[5]
Caractéristiques et avantages
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Notes préparatoires
Ganciclovir is soluble in 0.1 M HCl (10 mg/ml), DMSO (5 mg/ml), water (2 mg/ml), hot methanol, and ethanol (<1 mg/ml).
This product should be stored desiccated at 2-8 °C. Under these conditions the product is stable for 3 years.
This product should be stored desiccated at 2-8 °C. Under these conditions the product is stable for 3 years.
Ganciclovir is tested for solubility in 0.1M HCl at 10 mg/mL. The compound is also soluble in DMSO at 5 mg/mL.
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Muta. 1B - Repr. 2
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Certificats d'analyse (COA)
Lot/Batch Number
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The ability of herpes simplex virus type 1 thymidine kinase (HSV-TK)-expressing cells incubated with ganciclovir (GCV) to induce cytotoxicity in neighboring HSV-TK-negative (bystander) cells has been well documented. Although it has been suggested that this bystander cell killing occurs through
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Articles
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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Can Ganciclovir G2536 be dissolved in DMSO for in vitro testing?
1 answer-
Helpful?
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can ganciclovir be dissolved in PBS or saline? can ganciclovir be neutralized by 0.1M NaOH after dissolving in 0.1M HCl
1 answer-
Product G2536, Ganciclovir is tested for solubility in 0.1M HCl at 10 mg/mL. The compound is also soluble in DMSO at 5 mg/mL. While pH adjustment for neutralization has not been tested, this is a typical practice in pharmaceutical-grade solutions for injection. It is anticipated that no issues would arise regarding stability or precipitation.
See below for a link to a typical product insert, page 14 under Description:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209347lbl.pdfHelpful?
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Can ganciclovir be resuspended in solutions other than HCl? If so, what is the solubility and storage condition? Thank you.
1 answer-
References state that this chemical is soluble in 0.1 M HCl (10 mg/ml), DMSO (5 mg/ml), water (2 mg/ml), hot methanol, and ethanol (<1 mg/ml).
This product should be stored desiccated at 2-8 °C. Under these conditions the product is stable for 3 years.
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