E8515

β-Estradiol 3-benzoate

≥97%

• Synonyme(s) : 1,3,5(10)-estratriène-3,17β-diol 3-benzoate, 3,17β-dihydroxy-1,3,5(10)-estratriène 3-benzoate
• Formule empirique (notation de Hill) : C₂₅H₂₈O₃
• Numéro CAS: 50-50-0
• Poids moléculaire : 376.49
• UNSPSC Code: 51111800
• NACRES: NA.77
• PubChem Substance ID: 24894677
• EC Number: 200-043-7
• Beilstein/REAXYS Number: 3107526
• MDL number: MFCD00003692
• Assay: ≥97%

Propriétés

• Quality Segment: 200
• assay: ≥97%
• mp: 191-198 °C (lit.)
• SMILES string: [H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OC(=O)c5ccccc5)ccc24
• InChI: 1S/C25H28O3/c1-25-14-13-20-19-10-8-18(28-24(27)16-5-3-2-4-6-16)15-17(19)7-9-21(20)22(25)11-12-23(25)26/h2-6,8,10,15,20-23,26H,7,9,11-14H2,1H3/t20-,21-,22+,23+,25+/m1/s1
• InChI key: UYIFTLBWAOGQBI-BZDYCCQFSA-N

Description

Application

β-Estradiol 3-benzoate has been used:to mimic estradiol in rat during the oestrous cycle in rats. It has also been used along with progesterone for the induction of sexual receptivity in female rat.

Used in a study of general steroid metabolism and clearing, as groundwork for anabolic steroid screening in athletes.

Biochem/physiol Actions

β-Estradiol 3-benzoate is a synthetic estrogen. It favors breast cancer progression. It is an endocrine disrupting chemicals. It interacts with endocrine system and cause harmful effect on reproduction in animals and humans. It binds to estrogen receptors and favors tumor metastatis in breast, prostate and bone cells.

Informations sur la sécurité

• pictograms: GHS08
• signalword: Danger
• hcodes: H351,H360FD
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 2 - Repr. 1B
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges