If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
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For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
D1515
Doxorubicine hydrochloride
98.0-102.0% (HPLC)
Synonyme(s) :
Adriamycine, DOX, Hydroxydaunorubicine hydrochloride
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A propos de cet article
biological source
synthetic (organic)
Quality Segment
assay
98.0-102.0% (HPLC)
form
powder
mp
216 °C (dec.) (lit.)
solubility
water: 50.0-52.0 mg/mL, clear, orange to red
antibiotic activity spectrum
viruses
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key
MWWSFMDVAYGXBV-RUELKSSGSA-N
Gene Information
human ... TOP2A(7153)
General description
La doxorubicine provoque également la formation d'espèces réactives de l'oxygène (ERO), qui endommagent encore davantage l'ADN, les protéines et les membranes. Il présente une activité cytotoxique, antitumorale, anticancéreuse et antinéoplasique et est utilisé dans la recherche sur le cancer, en métabolomique, en biologie cellulaire et en biochimie.
Application
- Dans des tests de viabilité cellulaire.
- Dans un test au MTT (bromure de 3-(4,5-diméthylthiazol-2-yl)-2,5-diphényl tétrazolium).
- Comme médicament dans l′administration de médicament via des microparticules à base de polymère de PLGA.
- Pour développer des cellules HepG2 et K562 résistant à la doxorubicine (HepG2-DR, K562-DR).
Biochem/physiol Actions
Features and Benefits
- Antibiotique de grande qualité convenant à de nombreuses applications de recherche.
- Idéal pour la recherche en biologie cellulaire, en métabolomique et en biochimie.
Preparation Note
Other Notes
1 of 1
Cet article | |||
|---|---|---|---|
| description 98.0-102.0% (HPLC) | description Pharmaceutical Secondary Standard; Certified Reference Material | description United States Pharmacopeia (USP) Reference Standard | description suitable for fluorescence, 98.0-102.0% (HPLC) |
| antibiotic activity spectrum viruses | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum neoplastics |
| mode of action DNA synthesis | interferes | mode of action - | mode of action - | mode of action DNA synthesis | interferes, enzyme | inhibits |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level 200 |
| assay 98.0-102.0% (HPLC) | assay - | assay - | assay 98.0-102.0% (HPLC) |
| form powder | form powder | form - | form powder |
| solubility water: 50.0-52.0 mg/mL, clear, orange to red | solubility - | solubility - | solubility H2O: 50 mg/mL, clear, orange to red, DMSO: soluble, THF: soluble, ethanol: soluble, methanol: soluble |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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How to store after reconstitution and for how long is it stable?
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Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C. Avoid repeated freeze/thaw cycles.
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What is the difference between Doxorubicin hydrochloride Products D1515 and 44583?
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The D1515 and 44583 Doxorubicin HCl products are physically identical. Each has a minimum purity specification of 98%. However, the 44583 product option is tested for suitability in fluorescence applications while the D1515 is assigned basic tests for general research use.
The following links taken from the peer reviewed papers may be of interest:
https://www.sigmaaldrich.com/search/d1515?focus=papers&page=1&perpage=30&sort=relevance&term=d1515&type=citation_searchHelpful?
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Si può prolungare la stabilità del prodotto D1515 sciolto in soluzione acquosa e successivamente conservato a -20°C?
1 answer-
Solution stability studies have not been performed on this product, however, the available literature suggests that solutions are most stable refrigerated. It is recommended to add 3 - 5% glucose or lactose as a stabilizer for long-term storage. Commercially available solutions were found to be stable for at least 1 month at -20°C and up to 1 year at 4°C.
This product, in solution, will degrade in alkaline pH conditions or when exposed to light for extended periods.
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Whta is the pka and logP of Doxorubicin hydrochloride ID D1515
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See the link below to DrugBank Online for these data:
https://go.drugbank.com/salts/DBSALT000060Helpful?
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Is this product suitable for in vivo applications?
1 answer-
This product has not been tested for in vitro or in vivo use. However, the listed Peer-Reviewed Papers suggest that customers have been successful in these applications. Note that the product is not tested for endotoxin and the solution would require filter sterilization prior to use.
Please view the peer-reviewed papers here: https://www.sigmaaldrich.com/search/d1515?focus=papers&page=1&perpage=30&sort=relevance&term=d1515&type=citation_search.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the difference between Doxorubicin hydrochloride Products D1515 and D1317?
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Product No. D1317, Doxorubicin hydrochloride solution has been discontinued and is no longer available. We now offer Product No. D1515 which is a powder.
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What is the excitation and emission wavelength for Product D1515, Doxorubicin hydrochloride?
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Doxorubicin has excitation maximum at 470 nm and an emission maximum at 585 nm in ethanol.
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