Yes, this product is soluble in water at 50 mg/mL. PBS and other aqueous buffers would also be an option.
44583
Doxorubicine hydrochloride
suitable for fluorescence, 98.0-102.0% (HPLC)
Synonyme(s) :
DOX, Hydroxydaunorubicine hydrochloride
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About This Item
Formule empirique (notation de Hill):
C27H29NO11 · HCl
Numéro CAS:
Poids moléculaire :
579.98
Beilstein:
4229251
Numéro CE :
Numéro MDL:
Code UNSPSC :
51281818
ID de substance PubChem :
Nomenclature NACRES :
NA.76
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Source biologique
synthetic
Niveau de qualité
Essai
98.0-102.0% (HPLC)
Forme
solid
Couleur
orange to dark red
Pf
216 °C (dec.) (lit.)
Solubilité
H2O: 50 mg/mL, clear, orange to red
DMSO: soluble
THF: soluble
ethanol: soluble
methanol: soluble
Fluorescence
λem 580-590 nm
Adéquation
suitable for fluorescence
Spectre d'activité de l'antibiotique
neoplastics
Mode d’action
DNA synthesis | interferes
enzyme | inhibits
Température de stockage
2-8°C
Chaîne SMILES
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
Clé InChI
MWWSFMDVAYGXBV-RUELKSSGSA-N
Informations sur le gène
human ... TOP2A(7153)
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Description générale
Chemical structure: tetracycline
Application
Actions biochimiques/physiologiques
Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent [3].
Conditionnement
Bottomless glass bottle. Contents are inside inserted fused cone.
Autres remarques
Keep container tightly closed in a dry and well-ventilated place.
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Articles
Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.
Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.
Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.
Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.
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Doxorubicin (44583) can dissolve in PBS only or not?
1 answer-
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At what concentration can Doxorubicin hydrochloride, Product 44583, be dissolved in water? At what concentration in DMSO?
1 answer-
The solubility of Product No. 44583 tested in water (50 mg/mL), yielding a clear orange to red solution. It is also soluble in DMSO (50 mg/mL), ethanol, methanol and tetrahydrofuran.
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What is the function of Doxorubicin hydrochloride, Product 44583?
1 answer-
In chemotherapy: "Doxorubicin HCl is the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin." -National Cancer Institute.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How should I use Product D1515 - Doxorubicin hydrochloride to induce double strand breaks in the DNA of HeLa cells?
1 answer-
We do not test Product D1515 - Doxorubicin hydrochloride for biological activity with HELA cells. The following paper used 100 nM to 250 nM doxorubicin Adam Hermawan, et al., Journal of Natural Remedies, Vol. 12/2 (2012) 108-114The following paper uses 0.01 to 1.0 mug/ml doxorubicin SH Kim, et al., CANCER RESEARCH 32, 323-325, February 1972
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How stable is a solution of Doxorubicin hydrochloride, Product 44583?
1 answer-
According to the 11th edition of the chemicals encyclopedia published by the Royal Society of Chemistry, "aqueous solutions are unchanged after one month at 5 °C but unstable at higher temperatures or at either acid or alkaline pH. Several studies cite that stability is related to pH, exposure to light and the medium used for storage. Doxorubicin hydrochloride is subject to light degradation at °C in the dark in 5% glucose, pH 4.7 (or 3.3% glucose + 0.3% sodium chloride, pH 4.4), solutions were stable (5% or less change) for at least 4 weeks".
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