C4024

Carbamazepine

≥98% (HPLC), powder, antiepileptic agent

• Synonyme(s) : 5H-Dibenz[b,f]azepine-5-carboxamide
• Formule empirique (notation de Hill): C₁₅H₁₂N₂O
• Numéro CAS: 298-46-4
• Poids moléculaire : 236.27
• Numéro CE : 206-062-7
• Numéro MDL: MFCD00005073
• Code UNSPSC : 12352200
• eCl@ss : 34051404
• ID de substance PubChem : 57654002
• Nomenclature NACRES : NA.77

Propriétés

• product name: Carbamazepine, powder
• Forme: powder
• Niveau de qualité: 100
• Pf: 191-192 °C (lit.)
• Solubilité: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 29 mg/mL; H₂O: insoluble; ethanol: soluble; propylene glycol: soluble
• Auteur: Novartis
• Température de stockage: 2-8°C
• Chaîne SMILES: NC(=O)N1c2ccccc2C=Cc3ccccc13
• InChI: 1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
• Clé InChI: FFGPTBGBLSHEPO-UHFFFAOYSA-N
• Informations sur le gène: human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , PRNP(5621) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Scn2a1(24766) , Scnn1a(25122) , Scnn1g(24768) , Slc6a1(79212)

Description

Application

Carbamazepine has been used to investigate its behavior in wastewater treatment and during groundwater infiltration. It has also been used to find out its effects on spontaneous seizures in rats.

Actions biochimiques/physiologiques

Carbamazepine is considered as a safe antiepileptic drug. It decreases the multiple drug therapy and maintains a better control of epilepsy.

Anticonvulsant; ligand for the GABA_A receptor benzodiazepine modulatory site. Sodium channel inhibitor.

Caractéristiques et avantages

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H317,H334,H336,H360FD
• Conseils de prudence: P202 - P261 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Repr. 1A - Resp. Sens. 1 - Skin Sens. 1A - STOT SE 3
• Organes cibles: Central nervous system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves