The solubility of this product is not analyzed on a lot-to-lot basis. The compound is expected to be soluble in water at 0.4 mg/ml, ethanol at 2.6 mg/ml, methanol at 12.1 mg/ml, chloroform at 22.2 mg/ml, and DMSO at 50 mg/ml.
92131
Triméthoprime
≥99.0% (HPLC)
Synonyme(s) :
2,4-diamino-5-(3,4,5-triméthoxybenzyl)pyrimidine, NSC 106568
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About This Item
Formule empirique (notation de Hill):
C14H18N4O3
Numéro CAS:
Poids moléculaire :
290.32
Beilstein:
625127
Numéro CE :
Numéro MDL:
Code UNSPSC :
51285203
ID de substance PubChem :
Nomenclature NACRES :
NA.85
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Source biologique
synthetic
Niveau de qualité
Essai
≥99.0% (HPLC)
Forme
powder
Couleur
white to light yellow
Pf
≥199.0 °C
Spectre d'activité de l'antibiotique
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
Mode d’action
DNA synthesis | interferes
enzyme | inhibits
Température de stockage
2-8°C
Chaîne SMILES
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
InChI
1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
Clé InChI
IEDVJHCEMCRBQM-UHFFFAOYSA-N
Informations sur le gène
human ... DHFRP1(573971) , KCNH1(3756)
rat ... Dhfr(24312)
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Description générale
Chemical structure: pyrimidine
Application
Produit principalement utilisé comme agent antibactérien. Inhibiteur de la dihydrofolate réductase présentant une sélectivité pour l'enzyme procaryote.
Actions biochimiques/physiologiques
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Conditionnement
1g,5g,25g
Autres remarques
Keep container tightly closed in a dry and well-ventilated place.Light sensitive. Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral - Repr. 2
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Certificats d'analyse (COA)
Lot/Batch Number
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Les clients ont également consulté
R de Groot et al.
Antimicrobial agents and chemotherapy, 32(4), 477-484 (1988-04-01)
We studied 10 trimethoprim-resistant (Tmpr) Haemophilus influenzae isolates for which agar dilution MICs were 10 to greater than 200 micrograms/ml. Trimethoprim resistance was transferred from two Tmpr H. influenzae isolates to a Tmps strain by conjugation or transformation. Wild-type Tmpr
Susceptibility of Mycobacterium tuberculosis to sulfamethoxazole, trimethoprim and their combination over a 12 year period in Taiwan.
Tsi-Shu Huang1,2,3, Calvin M. Kunin, et al.
The Journal of Antimicrobial Chemotherapy, 10, 633-637 (2011)
Kate S Baker et al.
The Lancet. Infectious diseases, 15(8), 913-921 (2015-05-06)
Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is typically associated with travel to high-risk regions (Africa, Asia, and Latin America). Since the 1970s, shigellosis has also been reported as a sexually transmitted infection in men who
Kyuho Han et al.
Nature methods, 11(1), 86-93 (2013-11-12)
Protein concentrations are often regulated by dynamic changes in translation rates. Nevertheless, it has been challenging to directly monitor changes in translation in living cells. We have developed a reporter system to measure real-time changes of translation rates in human
Karin Tegmark Wisell et al.
The Journal of antimicrobial chemotherapy, 62(1), 35-40 (2008-04-15)
The lack of oral treatment alternatives for enterococcal urinary tract infections (UTIs) has led to a renewed interest in trimethoprim. Enterococci can incorporate exogenously produced folates and thereby reverse the effect of trimethoprim. Although a large proportion of enterococci appear
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Is Trimethoprim soluble in DMSO or water?
1 answer-
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Is Trimethoprim stable in solution?
1 answer-
Triemethoprim in a solution of 52% N,N dimethylacetamide:48% propylene glycol at 50 mg/ml is stable when stored at 25° C. There is only a 10% degradation of trimethoprim under these conditions after 885 days.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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