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Y0001574

Mesalazine for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

5-Aminosalicylic acid, 5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine

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About This Item

Formule linéaire :
H2NC6H3-2-(OH)CO2H
Numéro CAS:
89-57-6
Poids moléculaire :
153.14
Numéro Beilstein :
2090421
Numéro MDL:
MFCD00007877
Code UNSPSC :
41116107
ID de substance PubChem :
329831489
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

mesalazine, mesalamine

Fabricant/nom de marque

EDQM

Pf

275-280 °C (dec.) (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Nc1ccc(O)c(c1)C(O)=O

InChI

1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)

Clé InChI

KBOPZPXVLCULAV-UHFFFAOYSA-N

Informations sur le gène

human ... ALOX5(240) , PPARG(5468) , PTGS1(5742) , PTGS2(5743)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

PHR1060

Mesalamine, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1148

4-Aminophénol (composé K apparenté à l'acétaminophène) (Impureté K du paracétamol), Pharmaceutical Secondary Standard; Certified Reference Material

1021204

4-Aminophénol, United States Pharmacopeia (USP) Reference Standard

1633506

Sulfanilic acid, United States Pharmacopeia (USP) Reference Standard

PHR1225

3-Aminophenol, Pharmaceutical Secondary Standard; Certified Reference Material

Y0000297

Mesalazine, European Pharmacopoeia (EP) Reference Standard

Y0001563

4-Aminophénol, European Pharmacopoeia (EP) Reference Standard

Y0001569

2-Aminophenol, European Pharmacopoeia (EP) Reference Standard

PHR1419

Sulfanilic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

1392705

Mesalamine, United States Pharmacopeia (USP) Reference Standard

1026004

3-Aminophenol, United States Pharmacopeia (USP) Reference Standard

PHR1739

2-Aminophenol, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1741

2-Chloro-5-nitrobenzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1742

2-Hydroxy-nitrobenzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1745

4-Aminophenol hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

BP1075

Mesalazine, British Pharmacopoeia (BP) Reference Standard

PHR9052

3-Nitrosalicylic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR9053

2-Chloro-3-nitrobenzoic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR9056

2-Hydroxy-5-nitrobenzoic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR9138

3-Aminosalicylic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H317,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

No data available

Point d'éclair (°C)

No data available

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Certificats d'analyse (COA)

Lot/Batch Number

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Altamash I Qureshi et al.
Advanced drug delivery reviews, 57(2), 281-302 (2004-11-24)
Sulfasalazine's role as the first-line of therapy in patients with inflammatory bowel disease has led to the development of other "designer" aminosalicylates, which eliminate the sulfa-moiety, and attempt to target the topically active mesalamine to the inflamed bowel. Olsalazine sodium
P D R Higgins et al.
Alimentary pharmacology & therapeutics, 29(3), 247-257 (2008-10-24)
Ulcerative colitis (UC) can be maintained in remission with 5-aminosalicylic acid (5-ASA) medications, but frequent non-adherence by patients who are feeling well has been associated with more frequent flares of colitis. To perform a systematic review of the published literature
A H Steinhart et al.
Alimentary pharmacology & therapeutics, 25(12), 1389-1399 (2007-06-02)
To evaluate the effectiveness of pH 6-/pH 7-dependent and controlled-release mesalazines in maintaining medically and surgically induced Crohn's disease remission. A systematic search identified 13 randomized controlled trials (RCTs). The rate of symptomatic relapse (Crohn's disease activity index >150, or
Marietta Iacucci et al.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 24(2), 127-133 (2010-02-13)
5-aminosalicylic acid (5-ASA) preparations (eg, mesalazine, mesalamine) are well-established preparations used in the management of inflammatory bowel disease. These drugs are most useful for the treatment of mild to moderate flares of ulcerative colitis and, especially, for maintenance of remission.
Alexander C Ford et al.
The American journal of gastroenterology, 106(12), 2070-2077 (2011-09-07)
Maintenance therapy with 5-aminosalicylates (5-ASAs) is recommended in patients with quiescent ulcerative colitis (UC), but compliance rates are low. Once-daily dosing may improve adherence, but impact on the relapse of disease activity is unclear as no previous meta-analysis has studied
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