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Y0001432

Minoxidil for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Minoxidil, 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide

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About This Item

Formule empirique (notation de Hill):
C9H15N5O
Numéro CAS:
38304-91-5
Poids moléculaire :
209.25
Numéro MDL:
MFCD00063409
Code UNSPSC :
41116107
ID de substance PubChem :
329831424
Nomenclature NACRES :
NA.24
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Qualité

pharmaceutical primary standard

Famille d'API

minoxidil

Fabricant/nom de marque

EDQM

Pf

272-274 °C (dec.) (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

NC1=CC(=NC(=N)N1O)N2CCCCC2

InChI

1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2

Clé InChI

ZIMGGGWCDYVHOY-UHFFFAOYSA-N

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Minoxidil for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H315,H319,H335

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

R Colamarino et al.
Annales de medecine interne, 141(5), 425-428 (1990-01-01)
Topical minoxidil, used in the treatment of baldness, has been commercially available since 1987. Its systemic side effects are rare. We observed an as yet unreported "polymyalgia syndrome" in four otherwise healthy males whose sole medication was topically applied minoxidil.
R L DeVillez
Dermatologic clinics, 8(2), 367-375 (1990-04-01)
Topical minoxidil is a trichogenic agent that stimulates the hair follicle via the vasoactive metabolite minoxidil sulfate without any evidence of antiandrogen activity or an effect on the immune system. Less than 5% of the applied dose is absorbed. The
Susumu Otomo
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 119(3), 167-174 (2002-03-28)
The length and size of hair are depend on the anagen term in its hair cycle. It has been reported that the some cell growth factors, such as VEGF, FGF-5S, IGF-1 and KGF, induce the proliferation of cells in the
[Minoxidil. Objectivity and criticism].
F Bardazzi et al.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 124(9), 407-409 (1989-09-01)
Alfredo Rossi et al.
Recent patents on inflammation & allergy drug discovery, 6(2), 130-136 (2012-03-14)
Minoxidil, a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth, was first introduced, exclusively as an oral drug, to treat high blood pressure. It was however discovered to have the important side-effect
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