M4145

Minoxidil

≥99% (TLC), powder, potassium channel activator

• Synonyme(s) : 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
• Formule empirique (notation de Hill) : C₉H₁₅N₅O
• Numéro CAS: 38304-91-5
• Poids moléculaire : 209.25
• NACRES: NA.77
• PubChem Substance ID: 24277853
• UNSPSC Code: 12352200
• EC Number: 253-874-2
• MDL number: MFCD00063409
• Assay: ≥99% (TLC)

Propriétés

• Nom du produit: Minoxidil, ≥99% (TLC)
• Quality Segment: 100
• assay: ≥99% (TLC)
• mp: 272-274 °C (dec.) (lit.)
• originator: Johnson & Johnson
• SMILES string: NC1=CC(=NC(=N)N1O)N2CCCCC2
• InChI: 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
• InChI key: ZIMGGGWCDYVHOY-UHFFFAOYSA-N
• Gene Information: human ... KCNJ1(3758)

Description

Application

Minoxidil has been used as test drug:

• in dermal papilla spheroid model, to study the effect of hair regeneration
• administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury
• administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses

Biochem/physiol Actions

Activates ATP-activated K⁺ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves