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Y0000726

Dorzolamide hydrochloride

European Pharmacopoeia (EP) Reference Standard

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About This Item

Formule empirique (notation de Hill):
C10H16N2O4S3 · HCl
Numéro CAS:
130693-82-2
Poids moléculaire :
360.90
Numéro Beilstein :
5896026
Numéro MDL:
MFCD00884659
Code UNSPSC :
41116107
ID de substance PubChem :
329831117
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

dorzolamide

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

Cl.CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O

InChI

1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1

Clé InChI

OSRUSFPMRGDLAG-QMGYSKNISA-N

Informations sur le gène

human ... CA2(760)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dorzolamide hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1225281

Dorzolamide hydrochloride, United States Pharmacopeia (USP) Reference Standard

Y0000750

Dorzolamide for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0000727

Dorzolamide Impurity A, European Pharmacopoeia (EP) Reference Standard

1225292

Dorzolamide hydrochloride Related Compound A, United States Pharmacopeia (USP) Reference Standard

1225306

Dorzolamide Related Compound D, United States Pharmacopeia (USP) Reference Standard

BP1069

Dorzolamide hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP1071

Dorzolamide impurity D, British Pharmacopoeia (BP) Reference Standard

BP1070

Dorzolamide impurity B, British Pharmacopoeia (BP) Reference Standard

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H373

Classification des risques

Acute Tox. 4 Oral - STOT RE 2

Organes cibles

Central nervous system,Gastrointestinal tract,Bone,Blood,Bladder

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Timolol maleate United States Pharmacopeia (USP) Reference Standard

USP

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Sigma-Aldrich

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Timolol maleate salt

Ikuyo Ohguro et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 28(4), 392-396 (2012-04-07)
The purpose of the present study is to evaluate the effects of a fixed combination of 0.5% timolol maleate (TM) and 1% dorzolamide hydrochloride (DZ) (FCTD(1%)) on optic nerve head (ONH) blood circulation. A drop of 0.5% TM, 1% DZ
Vikas Gulati et al.
Archives of ophthalmology (Chicago, Ill. : 1960), 130(6), 677-684 (2012-02-15)
To evaluate the interaction of intraocular pressure(IOP)–lowering medications with physiologic day and night changes in aqueous humor dynamics in participants with ocular hypertension. Thirty participants were enrolled in thisdouble-masked, randomized, crossover study. Each participant underwent aqueous humor dynamics measurements at
Yasuhiro Ikeda et al.
The British journal of ophthalmology, 97(9), 1187-1191 (2013-06-21)
To evaluate the therapeutic effect of continuous treatment with topical dorzolamide (a carbonic anhydrase inhibitor) for cystoid macular oedema (CME) associated with retinitis pigmentosa (RP). 18 eyes in 10 patients with CME secondary to RP were included. Baseline visual acuity
Mohamed A Genead et al.
Retina (Philadelphia, Pa.), 32(4), 826-833 (2011-09-03)
: To determine the value of a topical carbonic anhydrase inhibitor on the macular thickness and function in choroideremia patients with cystoid macular edema. : Two choroideremia patients with cystoid macular edema, observed by spectral-domain optical coherence tomography, were treated
Mumin Hakan Eren et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 28(4), 381-386 (2012-02-11)
To compare the efficacy and safety of dorzolamide hydrochloride 2%/timolol maleate 0.5% fixed combination (DTFC) with latanoprost 0.005%/timolol maleate 0.5% fixed combination (LTFC) on diurnal intraocular pressure (IOP) in patients with primary open-angle glaucoma. Thirty-three primary open-angle glaucoma patients with
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