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T5500

Sigma-Aldrich

2-Thiobarbituric acid

≥98%

Synonyme(s) :

4,6-Dihydroxy-2-mercaptopyrimidine, 4,6-Dihydroxypyrimidine-2-thiol, TBA

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About This Item

Formule empirique (notation de Hill):
C4H4N2O2S
Numéro CAS:
504-17-6
Poids moléculaire :
144.15
Beilstein:
120663
Numéro CE :
207-985-8
Numéro MDL:
MFCD00006674
Code UNSPSC :
12352106
ID de substance PubChem :
24900285
Nomenclature NACRES :
NA.25
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Niveau de qualité

100

Essai

≥98%

Contrôle du médicament

regulated under CDSA - not available from Sigma-Aldrich Canada

Pf

245 °C (dec.) (lit.)

Chaîne SMILES 

O=C1CC(=O)NC(=S)N1

InChI

1S/C4H4N2O2S/c7-2-1-3(8)6-4(9)5-2/h1H2,(H2,5,6,7,8,9)

Clé InChI

RVBUGGBMJDPOST-UHFFFAOYSA-N

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Description générale

2-Thiobarbituric acid is a molecule made up of heteroatoms: nitrogen, sulphur and oxygen.[1]

Application

2-Thiobarbituric acid has been used to measure malondialdehyde (MDA) in lipid peroxidation assay.[2][3][4]

Actions biochimiques/physiologiques

2-Thiobarbituric acid (TBA) is useful to quantitate lipopolysaccharides, carrageenan, and sialic acids. It is also used to detect lipid hydroperoxides and lipid oxidation.[5] It has applications in the field of medicine and biochemistry. TBA may possess the ability to prevent metal corrosion.[1]

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
BCCM0391
BCCJ9029
BCCG7728
BCCD9501
BCCD1032

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Auricularia polytricha aqueous extract supplementation decreases hepatic lipid accumulation and improves antioxidative status in animal model of nonalcoholic fatty liver
Chiu WC, et al.
Biomedicine / [Publiee Pour L'A.A.I.C.I.G.], 4(2) (2014)
The inhibition effect of 2-thiobarbituric acid on the corrosion performance of mild steel in HCl solutions
Kardas G
Materials Science, 41(3), 337-343 (2005)
Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion
Nakano Y, et al.
The Journal of Surgical Research, 155(2), 311-317 (2009)
Evaluation of three 2-thiobarbituric acid methods for the measurement of lipid oxidation in various meats and meat products
Ulu H
Meat Science, 67(4), 683-687 (2004)
Leticia R Benetti et al.
European journal of pharmacology, 698(1-3), 463-469 (2012-11-28)
Recent studies show that endogenous hydrogen sulfide (H(2)S) plays an anti-inflammatory role in the pathogenesis of airway inflammation. This study investigated whether exogenous H(2)S may counteract oxidative stress-mediated lung damage in allergic mice. Female BALB/c mice previously sensitized with ovalbumin
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Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Is 2-thiobarbituric acid a DEA controlled susbtance

    1 answer

    1. This product is not a DEA controlled substance. Products that are DEA controlled will state this directly on the product website in the "Properties" Section.

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