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T0700000

Theobromine

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

2,6-Dihydroxy-3,7-dimethylpurine, 3,7-Dihydro-3,7-dimethyl-1H-purine-2,6-dione, 3,7-Dimethylxanthine

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About This Item

Formule empirique (notation de Hill):
C7H8N4O2
Numéro CAS:
83-67-0
Poids moléculaire :
180.16
Numéro Beilstein :
16464
Numéro MDL:
MFCD00022830
Code UNSPSC :
41116107
ID de substance PubChem :
329826614
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

theobromine

Fabricant/nom de marque

EDQM

Pf

345-350 °C

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

[H]N1C(N(C)C2=C(N(C)C=N2)C1=O)=O

InChI

1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)9-7(13)11(5)2/h3H,1-2H3,(H,9,12,13)

Clé InChI

YAPQBXQYLJRXSA-UHFFFAOYSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Theobromine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Phosphosdiesterase inhibitor; weak adenosine receptor antagonist; diuretic; smooth muscle relaxant.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H319

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Determination of theobromine, theophylline and caffeine in cocoa samples by a high-performance liquid chromatographic method with on-line sample cleanup in a switching-column system.
Brunetto R D M, et al.
Food Chemistry, 100(2), 459-467 (2007)
Analysis of caffeine, theobromine and theophylline in coffee by near infrared spectroscopy (NIRS) compared to high-performance liquid chromatography (HPLC) coupled to mass spectrometry.
Huck W C, et al.
Analytica Chimica Acta, 538(1-2), 195-203 (2005)
M U Eteng et al.
Plant foods for human nutrition (Dordrecht, Netherlands), 51(3), 231-243 (1997-01-01)
Caffeine and theobromine are purine alkaloids widely consumed as stimulants and snacks in coffee and cocoa based foods and most often as part of ingredients in drugs. Man has enjoyed a long history of consumption of caffeine and theobromine. Recent
B Stavric
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(8), 725-733 (1988-08-01)
This review provides a brief overview of known information on the human toxicity of theobromine and paraxanthine. Theobromine has some pharmacological effects, although these activities are considerably weaker than those of theophylline and/or caffeine, described in parts 1 and 2
Hendrik Jan Smit
Handbook of experimental pharmacology, (200)(200), 201-234 (2010-09-23)
The effects of theobromine in man are underresearched, possibly owing to the assumption that it is behaviourally inert. Toxicology research in animals may appear to provide alarming results, but these cannot be extrapolated to humans for a number of reasons.
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