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P0300000

Acétaminophène

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

4′-Hydroxyacétanilide, 4-Acétaminophène, N-(4-Hydroxyphényl)acétamide, N-Acétyl-4-aminophénol, APAP, Paracétamol

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About This Item

Formule linéaire :
CH3CONHC6H4OH
Numéro CAS:
103-90-2
Poids moléculaire :
151.16
Beilstein:
2208089
Numéro CE :
203-157-5
Numéro MDL:
MFCD00002328
Code UNSPSC :
41116107
ID de substance PubChem :
329820028
Nomenclature NACRES :
NA.24
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Qualité

pharmaceutical primary standard

Description

API family: acetaminophen

Famille d'API

paracetamol, acetaminophen

Fabricant/nom de marque

EDQM

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Pf

168-172 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

Clé InChI

RZVAJINKPMORJF-UHFFFAOYSA-N

Informations sur le gène

human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Analgésique.
Paracetamol EP reference standard, intended for use only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

PHR1005

Acétaminophène, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1148

4-Aminophénol (composé K apparenté à l'acétaminophène) (Impureté K du paracétamol), Pharmaceutical Secondary Standard; Certified Reference Material

PHR1149

Acetaminophen Related Compound J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1150

Composé F apparenté à l'acétaminophène, Pharmaceutical Secondary Standard; Certified Reference Material

1003009

Acétaminophène, United States Pharmacopeia (USP) Reference Standard

1021204

4-Aminophénol, United States Pharmacopeia (USP) Reference Standard

PHR1225

3-Aminophenol, Pharmaceutical Secondary Standard; Certified Reference Material

1003010

Acetaminophen Related Compound A, United States Pharmacopeia (USP) Reference Standard

PHR1531

Acetaminophen Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1530

Acetaminophen Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1612

Acetaminophen Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

1003027

Acetaminophen Related Compound B, United States Pharmacopeia (USP) Reference Standard

1003042

Acetaminophen Related Compound D, United States Pharmacopeia (USP) Reference Standard

1003100

Acetaminophen Related Compound J, United States Pharmacopeia (USP) Reference Standard

1003031

Acetaminophen Related Compound C, United States Pharmacopeia (USP) Reference Standard

PHR1642

Acetaminophen Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

1003064

Composé F apparenté à l'acétaminophène, United States Pharmacopeia (USP) Reference Standard

1026004

3-Aminophenol, United States Pharmacopeia (USP) Reference Standard

Y0001781

Acétaminophène, European Pharmacopoeia (EP) Reference Standard

PHR1745

4-Aminophenol hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

BP371

Acétaminophène, British Pharmacopoeia (BP) Reference Standard

Y0001945

Paracetamol impurity J, European Pharmacopoeia (EP) Reference Standard

Y0001955

4-Aminophénol, European Pharmacopoeia (EP) Reference Standard

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

364.3 °F - Pensky-Martens closed cup

Point d'éclair (°C)

184.6 °C - Pensky-Martens closed cup

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Karel Allegaert et al.
Archives of disease in childhood, 98(6), 462-466 (2013-04-23)
There remains a need for alternative medical treatments for patent ductus arteriosus (PDA) closure in extreme preterm neonates because of therapeutic failure and adverse effects associated with non-selective cyclo-oxygenase inhibitors. Reports of an association between paracetamol exposure and PDA closure
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
Garry G Graham et al.
Drug safety, 28(3), 227-240 (2005-03-01)
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported
Garry G Graham et al.
Inflammopharmacology, 21(3), 201-232 (2013-05-31)
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective
Edward Munsterhjelm et al.
Anesthesiology, 103(4), 712-717 (2005-09-30)
Acetaminophen (paracetamol) is widely used for postoperative analgesia. Its mechanism of action is inhibition of prostaglandin synthesis in the central nervous system, and acetaminophen is traditionally not considered to influence platelet function. The authors studied the dose-dependent inhibition of platelet
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is the packing size of this Product (P0300000)?

    1 answer

    1. This is supplied as a 50 mg package. The product is supplied by the European Pharmacopoeia and the package size may be subject to change. To check the EP current unit quantity, please visit: https://crs.edqm.eu/db/4DCGI/View=P0300000

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