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M0605000

Metformin hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

1,1-Dimethylbiguanide hydrochloride, Metformin

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About This Item

Formule linéaire :
NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
Numéro CAS:
1115-70-4
Poids moléculaire :
165.62
Numéro MDL:
MFCD00012582
Code UNSPSC :
41116107
ID de substance PubChem :
329817811
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Agence

EP Reference standard

Famille d'API

metformin

Fabricant/nom de marque

EDQM

Pf

223-226 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

Cl[H].CN(C)C(=N)NC(N)=N

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

Clé InChI

OETHQSJEHLVLGH-UHFFFAOYSA-N

Informations sur le gène

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Metformin hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1396310

Metformin Related Compound A, United States Pharmacopeia (USP) Reference Standard

1396309

Metformin hydrochloride, United States Pharmacopeia (USP) Reference Standard

PHR1331

Metformin Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

Y0001590

Metformin impurity A, European Pharmacopoeia (EP) Reference Standard

Y0001600

Metformin impurity F, European Pharmacopoeia (EP) Reference Standard

1396331

Metformin Related Compound B, United States Pharmacopeia (USP) Reference Standard

1396342

Metformin Related Compound C, United States Pharmacopeia (USP) Reference Standard

PHR1505

Metformin Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1506

Metformin Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1532

Metformin Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

BP227

Metformin hydrochloride, British Pharmacopoeia (BP) Reference Standard

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H319

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Consulter la Bibliothèque de documents

Yen-Hsiang Chang et al.
Frontiers in endocrinology, 11, 445-445 (2020-08-28)
Background: Plenty of evidence suggested that chronic low-grade inflammation triggered by innate immunity activation contributes to the pathogenesis of type 2 diabetes (T2D). Using the trans-mitochondrial cybrid cell model, we have demonstrated that mitochondria independently take part in the pathological
Emi Kawakita et al.
Molecular cancer research : MCR, 19(1), 61-73 (2020-10-01)
The biological influence of antidiabetic drugs on cancer cells and diabetic cancer patients has not yet been completely elucidated. We reported that a dipeptidyl peptidase (DPP)-4 inhibitor accelerates mammary cancer metastasis by inducing epithelial-mesenchymal transition (EMT) through the CXCL12/CXCR4/mTOR axis.
Nicolas Musi et al.
Diabetes, 51(7), 2074-2081 (2002-06-28)
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic glucose production and increasing glucose disposal in skeletal muscle; however, the molecular site of metformin action is not well understood. AMP-activated protein kinase (AMPK) activity increases
L C Morin-Papunen et al.
The Journal of clinical endocrinology and metabolism, 85(9), 3161-3168 (2000-09-22)
Metformin, a biguanide antihyperglycemic drug, has been shown to improve ovarian function and glucose metabolism in women with polycystic ovary syndrome (PCOS), but results concerning its effects on insulin sensitivity are controversial. Oral contraceptive pills are commonly used in the
J De Jager et al.
Journal of internal medicine, 257(1), 100-109 (2004-12-21)
The UK Prospective Diabetes Study (UKPDS) showed that treatment with metformin decreases macrovascular morbidity and mortality independent of glycaemic control. We hypothesized that metformin may achieve this by improving endothelial function and chronic, low-grade inflammation. Data on this issue are
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