SCT092
BioTracker PyrPeg Amyloid-b Live Cell Dye
Synonyme(s) :
BioTracker PyrPeg Amyloid-b Live Cell Dye
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About This Item
Code UNSPSC :
12352207
Nomenclature NACRES :
NA.47
Produits recommandés
Forme
lyophilized
Poids mol.
calculated mol wt 459.49
Conditionnement
pkg of 1 mg
Fabricant/nom de marque
Millipore
Conditions de stockage
protect from light
Mode de croissance
N/A
Conditions d'expédition
ambient
Température de stockage
−20°C
Description générale
Alzheimer′s disease (AD) is a progressive neurological disorder characterized by the presence of amyloid-beta (Aβ) plagues and neurofibrillary tangles. The accumulation of Aβ plaques is an early event in the pathogenesis of AD. In AD research, there has been a growing need for in vivo Aβ imaging by two-photon microscopy, which enables deep-brain-fluorescence imaging. BioTracker PyrPeg Amyloid-b Live Cell Dye is a two-photon fluorescent probe that specifically detects insoluble Aβ, rather than tau and alpha-synuclein aggregates (1). This probe may serve as a useful blood-brain-barrier penetrating tool for optical and functional monitoring of insoluble forms of Aβ aggregates in the AD model brain (1).Reference:1. Choi, Ji-Woo, et al. "PyrPeg, a Blood–Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates." ACS Chemical Neuroscience 11.12 (2020): 1801-1810.
Application
Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
Caractéristiques et avantages
Two-photon fluorescent probe for imaging insoluble forms of Amyloid-beta aggregates in Alzheimer′s disease studies.
Forme physique
Lyophilized. Orange solid.
Stockage et stabilité
Store at -20°C, desiccate and protect from light.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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