MAB5258A4

Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor^™ 488 Conjugate

clone SY38, from mouse, ALEXA FLUOR^™ 488

• Synonyme(s) : Synaptophysin, Major synaptic vesicle protein p38
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Conjugué: ALEXA FLUOR^™ 488
• Forme d'anticorps: purified antibody
• Type de produit anticorps: primary antibodies
• Clone: SY38, monoclonal
• Espèces réactives: mouse, human
• Réactivité de l'espèce (prédite par homologie): bovine (immunogen homology)
• Technique(s): immunohistochemistry: suitable
• Isotype: IgG1
• Numéro d'accès NCBI: NP_776388
• Numéro d'accès UniProt: P20488
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... SYP(6855)

Description

Description générale

Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38 kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. The localization and ubiquitous expression of this protein in neuronal tissue makes it an excellent marker for neurons and neuroendocrine tumors. The gene for this protein is located on the X chromosome (Xp11.23-p11.22). The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.

Spécificité

This antibody reacts with presynaptic vesicles of cerebral and spinal neurons, of neuromuscular endplates and with the retina of man, cow, rat and mouse. It also reacts with vesicles of adrenal medulla and islet cells.

Immunogène

Vesicular fraction of bovine brain

Application

Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor 488 Conjugate detects level of Synaptophysin & has been published & validated for use in IH.

Research Category
Neuroscience

Research Sub Category
Neuronal & Glial Markers

Qualité

Evaluated by Immunohistochemistry in adult mouse brain tissue.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Synaptophysin in adult mouse brain tissue.

Description de la cible

The unconjugated parent antibody (Cat. No. MAB5258) has an observed molecular weight at ~38 kDa

Forme physique

Protein G purified

Purified mouse monoclonal IgG1κ conjugated to Alexa Fluor^™ 488 in buffer containing 15 mg/ml BSA with 0.1% sodium azide.

Stockage et stabilité

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Remarque sur l'analyse

Control
Adult mouse brain tissue

Autres remarques

Uncongugated antibody (MAB5258) is shown to work on Rat.

Informations légales

ALEXA FLUOR is a trademark of Life Technologies

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable