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Merck
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Key Documents

19-143

Sigma-Aldrich

PD 98059

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About This Item

Code UNSPSC :
12352202
eCl@ss :
32160405
Nomenclature NACRES :
NA.41

Forme

solid

Niveau de qualité

Fabricant/nom de marque

Upstate®

Technique(s)

activity assay: suitable (kinase)

Conditions d'expédition

wet ice

Application

Potent, selective and cell-permeable inhibitor of MAPK kinase, MAPK/ERK, or MEKK.

Actions biochimiques/physiologiques

Inhibitor Type: Kinase

Forme physique

C16H13NO3

Stockage et stabilité

2 years at -20°C

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3


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Xin Liu et al.
Non-coding RNA research, 9(3), 901-912 (2024-04-15)
DNA methylation is a crucial epigenetic alteration involved in diverse biological processes and diseases. Nevertheless, the precise role of DNA methylation in chemotherapeutic drug-induced alopecia remains unclear. This study examined the role and novel processes of DNA methylation in regulating
Shang Li et al.
NPJ biofilms and microbiomes, 9(1), 47-47 (2023-07-09)
Knowledge gaps that limit the development of therapies for polycystic ovary syndrome (PCOS) concern various environmental factors that impact clinical characteristics. Circadian dysrhythmia contributes to glycometabolic and reproductive hallmarks of PCOS. Here, we illustrated the amelioration of Limosilactobacillus reuteri (L.
D R Alessi et al.
The Journal of biological chemistry, 270(46), 27489-27494 (1995-11-17)
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1) and a mutant MAPKK1(S217E,S221E), which has low levels of constitutive activity (Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., and
Qize Wei et al.
Molecular biology of the cell, 13(2), 683-697 (2002-02-21)
We ectopically expressed the transcription factor Pitx2a, one of the Pitx2 isoforms, in HeLa cells by using a tetracycline-inducible expression system and examined whether Pitx2a was capable of modulating Rho GTPase signaling and altering the cell's cytoskeleton. Ectopic expression of
L Pang et al.
The Journal of biological chemistry, 270(23), 13585-13588 (1995-06-09)
The mitogen-activated protein kinase (MAP kinase) pathway is thought to play an important role in the actions of neurotrophins. A small molecule inhibitor of the upstream kinase activator of MAP kinase, MAP kinase kinase (MEK) was examined for its effect

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