09-069
Anti-ATF6 Antibody
Upstate®, from rabbit
Synonyme(s) :
Anti-ACHM7, Anti-ATF6A
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
polyclonal
Produit purifié par
affinity chromatography
Espèces réactives
human
Fabricant/nom de marque
Upstate®
Technique(s)
western blot: suitable
Isotype
IgG
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... ATF6(22926)
Description générale
ATF6 (Activating Transcription Factor 6, Cyclic AMP-dependent transcription factor ATF6) is a stress activated leucine zipper transcription factor involved in activating transcription of endoplasmic reticulum (ER) molecules in response to accumulation of unfolded proteins in the ER. ATF6 is originally a 90 kDa type II transmembrane glycoprotein that is converted to a 50 kDa soluble nuclear form, retaining its N-terminal domain, including the leucine zipper. Unfolded protein accumulation in the ER results in the cleavage of ATF6 to release its cytoplasmic domain that then enters the nucleus. ATF6 binds to an element designated ER Stress Response Element (ERSA) that appears in the promoter of glucose-regulated proteins (GRPs) such as GRP78, GPR94, and calreticulin.
Immunogène
KLH-tagged synthestic peptide synthesized to the N-terminal region of human ATF6 designated as the Cytoplasmic Domain.
Application
Detect ATF6 using this Anti-ATF6 Antibody validated for use in WB.
Research Category
Signaling
Epigenetics & Nuclear Function
Signaling
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Qualité
Routinely evaluated by western blot on HeLa lysate.
Description de la cible
90 kDa
Forme physique
Affinity purified
Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide.
Stockage et stabilité
1 year at -20°C
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Raphaël Santinelli et al.
Cells, 13(2) (2024-01-22)
Cystic Fibrosis (CF) is present due to mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, the most frequent variant being p.phe508del. The CFTR protein is a chloride (Cl-) channel which is defective and almost absent of cell membranes
Benjamin L Farah et al.
Molecular genetics and metabolism, 122(3), 95-98 (2017-09-11)
GSD Ia (von Gierke Disease, Glycogen Storage Disease Type Ia) is a devastating genetic disorder with long-term sequelae, such as non-alcoholic fatty liver disease and renal failure. Down-regulated autophagy is involved in the development of hepatic metabolic dysfunction in GSD
Michael J Rigby et al.
Communications biology, 4(1), 454-454 (2021-04-14)
Nε-lysine acetylation in the ER lumen is a recently discovered quality control mechanism that ensures proteostasis within the secretory pathway. The acetyltransferase reaction is carried out by two type-II membrane proteins, ATase1/NAT8B and ATase2/NAT8. Prior studies have shown that reducing
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