07-1491

Anti-Calcineurin pan A Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform, calcineurin A alpha, protein phosphatase 3 (formerly 2B), catalytic subunit, ; ; alpha isoform, protein phosphatase 3 (formerly 2B), catalytic subunit, ; ; alp
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100; 200
• Conjugué: conjugate
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: liquid
• Produit purifié par: affinity chromatography
• Espèces réactives: human, rat, mouse
• Réactivité de l'espèce (prédite par homologie): mammals (based on 100% sequence homology)
• Technique(s): western blot: suitable
• Séquence immunogène: KLH-conjugated synthetic peptide corresponding to Calcineurin.
• Numéro d'accès NCBI: NP_000935.1
• Numéro d'accès UniProt: Q08209
• Conditions d'expédition: wet ice
• Température de stockage: −20°C

Description

Description générale

Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin′s multifunctional capabilities in the regulation of calcium signaling.

Spécificité

This antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species.

Immunogène

KLH-conjugated synthetic peptide corresponding to Calcineurin.

Application

Detect Calcineurin pan A using this Anti-Calcineurin pan A Antibody validated for use in WB.

Research Category
Signaling

Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

Qualité

Evaluated by Western Blot in Mouse brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.

Description de la cible

~58 kDa

Liaison

Replaces: AB1695

Forme physique

Affinity purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative.

Stockage et stabilité

Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
remain unfrozen.

Remarque sur l'analyse

Control
Mouse brain lysate

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable