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D-916

Supelco

N-Desmethylclomipramine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formule empirique (notation de Hill):
C18H21ClN2 · HCl
Numéro CAS:
29854-14-6
Poids moléculaire :
337.29
Numéro CE :
200-659-6
Numéro MDL:
MFCD00792880
Code UNSPSC :
41116107
ID de substance PubChem :
329798895
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Niveau de qualité

300

Forme

liquid

Caractéristiques

Snap-N-Spike®/Snap-N-Shoot®

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

Concentration

1.0 mg/mL in methanol (as free base)

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

clinical testing

Format

single component solution

Température de stockage

−20°C

Chaîne SMILES 

ClC1=CC2=C(C=C1)CCC3=C(C=CC=C3)N2CCCNC.[H]Cl

InChI

1S/C18H21ClN2.ClH/c1-20-11-4-12-21-17-6-3-2-5-14(17)7-8-15-9-10-16(19)13-18(15)21;/h2-3,5-6,9-10,13,20H,4,7-8,11-12H2,1H3;1H

Clé InChI

KMDDAZOLOSKTKZ-UHFFFAOYSA-N

Catégories apparentées

Description générale

N-Desmethylclomipramine is a primary plasma metabolite of the tricyclic antidepressant clomipramine. Clomipramine is a tricyclic antidepressant used to treat many conditions from major depression and panic disorder to narcolepsy and obsessive compulsion disorder (OCD). This Certified Snap-N-Spike® Solution is applicable for use in urine drug testing, clinical toxicology, or forensic analysis by LC-MS/MS or GC/MS.

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

49.5 °F - closed cup

Point d'éclair (°C)

9.7 °C - closed cup

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

T Noguchi et al.
Journal of affective disorders, 29(4), 267-279 (1993-12-01)
We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N-desmethylclomipramine, 8-hydroxyclomipramine in 65 depressed patients with subtypes of DSM-III-R mood disorders receiving clomipramine hydrochloride. There were large interindividual variations in the concentrations of the parent and each of
L Palego et al.
Progress in neuro-psychopharmacology & biological psychiatry, 25(3), 519-533 (2001-05-24)
1. The authors present here a sensitive and rapid reversed-phase liquid chromatographic method which enables the simultaneous analysis in plasma of two different drugs and their metabolites: the atypical neuroleptic clozapine and the tricyclic antidepressant clomipramine. 2. Samples and the
Akihiro Takano et al.
Psychopharmacology, 216(2), 279-286 (2011-02-22)
Norepinephrine transporter (NET) is one of the key targets for antidepressants such as combined serotonin and norepinephrine reuptake inhibitors as well as some of the tricyclic antidepressants. Clomipramine, a tricyclic antidepressant, has been reported to have an active metabolite, desmethylclomipramine
J N King et al.
American journal of veterinary research, 61(1), 74-79 (2000-01-12)
To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs after IV or oral administration of a single dose. 6 male and 6 female Beagles. Clomipramine was administered IV (2 mg/kg), PO (4 mg/kg) after
C J Hewson et al.
Journal of veterinary pharmacology and therapeutics, 21(3), 214-222 (1998-07-23)
Clomipramine is a tricyclic antidepressant that has been recommended for the treatment of canine compulsive disorder. The pharmacokinetics of clomipramine in dogs have not been reported. This study describes the pharmacokinetics of clomipramine and its active metabolite, desmethylclomipramine, in six
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