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D-079

Supelco

Demoxepam solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formule empirique (notation de Hill):
C15H11ClN2O2
Numéro CAS:
963-39-3
Poids moléculaire :
286.71
Numéro MDL:
MFCD00868147
Code UNSPSC :
41116107
ID de substance PubChem :
329798639
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Forme

liquid

Caractéristiques

Snap-N-Spike®/Snap-N-Shoot®

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

Concentration

1.0 mg/mL in acetonitrile

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

clinical testing

Format

single component solution

Température de stockage

−20°C

Chaîne SMILES 

ClC1=CC=C(NC(C[N+]([O-])=C2C3=CC=CC=C3)=O)C2=C1

InChI

1S/C15H11ClN2O2/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)18(20)9-14(19)17-13/h1-8H,9H2,(H,17,19)

Clé InChI

GGRWZBVSUZZMKS-UHFFFAOYSA-N

Catégories apparentées

Description générale

A benzodiazepine drug and anticonvulsant, demoxepam is also a primary metabolite of chlordiazepoxide, marketed as Klopoxid or Librax® for the treatment of anxiety and muscle spasms or pain.

Application


  • Pharmacokinetic and Pharmacodynamic Analysis: A study discussed the rapid hydrolysis of chlordiazepoxide to Demoxepam, emphasizing the importance of understanding metabolic pathways in benzodiazepine analogues research. This knowledge aids in the design of neuropharmacology experiments and the development of GABA receptor agonist studies (Vinkers et al., 2010).

  • Neuropharmacological Studies: Research utilizing Demoxepam has explored its role as a benzodiazepine receptor ligand, which provides insight into its function as a neuropharmacology research chemical. These studies contribute to our understanding of Demoxepam′s effects on anxiety and its potential therapeutic applications (Lister et al., 1984).

  • High-Performance Liquid Chromatography (HPLC) Applications: The application of HPLC in the determination of 1,4-benzodiazepines and their metabolites, including Demoxepam, highlights its utility in the precise measurement of these compounds in plasma. This is crucial for biochemical assays and enhances the research reagent′s reliability in pharmaceutical industry studies (Skellern et al., 1978).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Librax is a registered trademark of Valeant Pharmaceuticals North America LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

FlameExclamation mark
GHS02,GHS07

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

35.6 °F - closed cup

Point d'éclair (°C)

2 °C - closed cup

Certificats d'analyse (COA)

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H Sidransky et al.
Biochemical medicine and metabolic biology, 47(3), 270-273 (1992-06-01)
Since some patients with eosinophilia-myalgia syndrome ingested tryptophan along with benzodiazepines, we investigated whether demoxepam, the N-desalkylated compound of chlordiazepoxide, would influence the binding of tryptophan to hepatic nuclei. L-Tryptophan has been shown to bind (saturable, stereospecific, and of high
Moustapha Ouédraogo et al.
Drug and chemical toxicology, 32(4), 417-423 (2009-10-02)
The cytotoxicity of oxaziridines photogenerated after irradiation of chlordiazepoxide (CDZ) and its metabolites was investigated in vitro by a MTT assay on P388 leukemia and B16 melanoma cell lines and compared with that of the anticancer drug, melphalan. For the
A G Davidson
Journal of pharmaceutical sciences, 73(1), 55-58 (1984-01-01)
Rapid difference spectrophotometric methods for chlordiazepoxide and demoxepam in chlordiazepoxide formulations are described which overcome the nonspecificity of the official spectrophotometric assays. The procedures are based on the measurement of the difference absorbance at 269 nm of equimolar solutions of
U A Brinkman et al.
Journal of chromatography, 217, 463-471 (1981-11-06)
Upon irradiation with short-wavelength UV light the tranquillizer demoxepam is converted into a highly fluorescent product. This reaction serves as a sensitive and selective means of detection of low levels of demoxepam in e.g., serum after separation by means of
Christiaan H Vinkers et al.
Psychopharmacology, 208(4), 555-562 (2010-01-13)
In chronic studies, the classical benzodiazepine chlordiazepoxide (CDP) is often the preferred drug because, unlike other benzodiazepines, it is soluble in water. However, rapid CDP hydrolysis in solution has been described. This would diminish plasma levels in chronic minipump studies
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