Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

810205X

Avanti

NBD Sphingosine

omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol, chloroform:methanol (8:2)

Synonyme(s) :

D-erythro-Sphingosine-N-NBD

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C24H39N5O5
Numéro CAS:
799268-47-6
Poids moléculaire :
477.60
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Pureté

>99% (TLC)

Forme

liquid

Conditionnement

pkg of 1 × 1 mL (810205X-250ug)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 810205X

Concentration

0.25 mg/mL (810205X-250ug)

Conditions d'expédition

dry ice

Température de stockage

−20°C

Description générale

Sphingosine is the most bioactive sphingoid with the common long chain base in sphingolipids. It is a constituent of the cell membrane. 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) sphingosine is a derivative of sphingosine attached with the fluorescent probe, NBD group.

Application

NBD Sphingosine or omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol may be used:
  • as a negative control to determine the binding of Atg12-Atg5 conjugate with phosphatidylethanolamine (PE)-containing liposomes
  • to label sphingosine kinase 1 (SphK1) in order to determine its role in endocytic membrane trafficking
  • to generate 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-ceramide C16

Actions biochimiques/physiologiques

Sphingosine serves as a precursor for ceramide. It is involved in the inhibition of protein kinase C in human platelets.

Conditionnement

5 mL Amber Glass Screw Cap Vial (810205X-250ug)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 1 - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

>125.5 °F

Point d'éclair (°C)

> 51.95 °C

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

F-Xabier Contreras et al.
Biophysical journal, 90(11), 4085-4092 (2006-03-15)
Sphingosine, at 5-15 mol % total lipids, remarkably increases the permeability to aqueous solutes of liposomal and erythrocyte ghost membranes. The increased permeability cannot be interpreted in terms of leakage occurring at the early stages of a putative membrane solubilization
Sphingosine increases the permeability of model and cell membranes
Contreras FX, et al.
Biophysical Journal, 90(11), 4085-4092 (2006)
Kamilah Castro et al.
EBioMedicine, 43, 392-410 (2019-04-15)
Multiple Sclerosis (MS) results from genetic predisposition and environmental variables, including elevated Body Mass Index (BMI) in early life. This study addresses the effect of BMI on the epigenome of monocytes and disease course in MS. Fifty-four therapy-naive Relapsing Remitting
Dan-Dan Song et al.
Cell death & disease, 8(7), e2912-e2912 (2017-07-07)
Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in neural cells. In both primary murine cortical neurons
Santiago Lima et al.
The Journal of biological chemistry, 292(8), 3074-3088 (2017-01-05)
The balance between cholesterol and sphingolipids within the plasma membrane has long been implicated in endocytic membrane trafficking. However, in contrast to cholesterol functions, little is still known about the roles of sphingolipids and their metabolites. Perturbing the cholesterol/sphingomyelin balance
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique