251569

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

98%, for peptide synthesis

• Synonyme(s) : 1,3-Dimethyl-2-oxohexahydropyrimidine, N,N′-Dimethylpropylene urea, DMPU
• Formule empirique (notation de Hill): C₆H₁₂N₂O
• Numéro CAS: 7226-23-5
• Poids moléculaire : 128.17
• Numéro Beilstein : 110562
• Numéro CE : 230-625-6
• Numéro MDL: MFCD00006550
• Code UNSPSC : 12352115
• ID de substance PubChem : 24855140
• Nomenclature NACRES : NA.22

Propriétés

• product name: 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone, 98%
• Niveau de qualité: 200
• Pureté: 98%
• Forme: liquid
• Indice de réfraction: n20/D 1.488 (lit.)
• Point d'ébullition: 146 °C/44 mmHg (lit.)
• Densité: 1.06 g/mL at 25 °C (lit.)
• Application(s): peptide synthesis
• Chaîne SMILES: CN1CCCN(C)C1=O
• InChI: 1S/C6H12N2O/c1-7-4-3-5-8(2)6(7)9/h3-5H2,1-2H3
• Clé InChI: GUVUOGQBMYCBQP-UHFFFAOYSA-N

Description

Application

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) can be used:

• As a versatile solvent in N-alkylation of amines
• O-alkylation of aldoses , and in the synthesis of poly(aryl ethers).
• As urea solvent in the synthesis of 1-aryl-3,4,5-substituted pyrazoles by cyclocondensation of arylhydrazine hydrochlorides with 1,3-diketones.
• As an additive in asymmetric cyanoamidation.

DMPU/HF can be used as a nucleophilic fluorinating agent in fluoro-Prins reaction for the synthesis of substituted 4-fluorotetrahydropyrans and 4-fluoropiperidines.

Versatile solvent employed in N-alkylation of chiral, primary amines, O-alkylation of aldoses, and in the synthesis of poly(aryl ethers).

Informations sur la sécurité

• Pictogrammes: GHS08,GHS05,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H318,H361f
• Conseils de prudence: P202 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 249.8 °F - closed cup
• Point d'éclair (°C): 121 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter