C2313

Compound 48/80

powder,  hypotensive agent

• Synonym(s): Poly-p-methoxyphenethylmethylamine
• UNSPSC Code: 41106300
• NACRES: NA.77

Properties

• product name: Compound 48/80,
• form: powder
• Quality Level: 200
• solubility: H₂O: 50 mg/mL
• storage temp.: −20°C

Description

General description

Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.

Application

Compound 48/80 has been used:

• to stimulate hemocytes for histamine release for measurement in ELISA and flow cytometry
• to induce mast cell degranulation
• to induce anaphylactic activity, dermatitis, pruritis, inflammation in mice

Biochem/physiol Actions

Compound 48/80 (C 48/80) is a hypotensive agent, which promotes release of histamine. C 48/80 reduces the phagocytic ability of hemocytes in Styela plicata. C 48/80 promotes degranulation of mast cells. It Inhibits calmodulin, phospholipase C, endoplasmic reticulum (ER) Ca²⁺ ATPase and activates G proteins.

Preparation Note

Condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301 + H311 + H331
• Precautionary Statements: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves