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Key Documents

8.03945

Sigma-Aldrich

Iron(III) chloride

greener alternative

anhydrous for synthesis

Synonym(s):

Iron(III) chloride, Ferric chloride, Iron trichloride

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About This Item

Empirical Formula (Hill Notation):
Cl3Fe
CAS Number:
7705-08-0
Molecular Weight:
162.20
MDL number:
MFCD00011005
UNSPSC Code:
12352302
EC Index Number:
231-729-4
NACRES:
NA.22

vapor pressure

1 hPa ( 20 °C)

Quality Level

200

form

powder

potency

316 mg/kg LD50, oral (Rat)

greener alternative product characteristics

Catalysis
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pH

1 (20 °C, 200 g/L in H2O)

mp

306 °C (decomposition)

solubility

920 g/L (Hydrolysis)

density

2.89 g/cm3 at 25 °C

bulk density

1000 kg/m3

greener alternative category

, Aligned

storage temp.

2-30°C

InChI

1S/3ClH.Fe/h3*1H;/q;;;+3/p-3

InChI key

RBTARNINKXHZNM-UHFFFAOYSA-K

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General description

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Application

Iron(III) chloride (FeCl3) can be used as a catalyst:
  • For the oxidation of glucose to gluconic acid in water.
  • To synthesize 2-iodo substituted benzo[b]thiophenes by iodocyclization of 2-alkynylthioanisoles in the presence of sodium iodide and ethanol as a solvent.
  • In the glycosylation sugars in the presence of allyl and alkynyl alcohols to synthesize corresponding glycosides.
  • To prepare 1,2-trans glycosyl azides by azido glycosylation of glycosyl β-peracetates.

Analysis Note

Assay (iodometric): ≥ 98.0 %
Identity (Fe): passes test
Identity (Cl): passes test

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H290,H302,H315,H317,H318

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

8B - Non-combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Santosh B Salunke et al.
Chemical communications (Cambridge, England), 47(37), 10440-10442 (2011-08-16)
A highly efficient and mild method for azido glycosylation of glycosyl β-peracetates to 1,2-trans glycosyl azides was developed by using inexpensive FeCl(3) as the catalyst. In addition, we demonstrated, for the first time, that FeCl(3) in combination with copper powder
Iron (III) chloride catalyzed glycosylation of peracylated sugars with allyl/alkynyl alcohols
Narayanaperumal S, et al.
Journal of the Brazilian Chemical Society, 23, 1982-1988 (2012)
Oxidative conversion of glucose to gluconic acid by iron (III) chloride in water under mild conditions
Zhang H, et al.
Green Chemistry, 18(8), 2308-2312 (2016)
Green synthesis of benzo [b] thiophenes via iron (III) mediated 5-endo-dig iodocyclization of 2-alkynylthioanisoles
Kesharwani T, et al.
Tetrahedron Letters, 57(3), 411-414 (2016)

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