T1019

(±)-Thiopental

• Synonym(s): 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid, Pentothal
• Empirical Formula (Hill Notation): C₁₁H₁₈N₂O₂S
• CAS Number: 76-75-5
• Molecular Weight: 242.34
• NACRES: NA.77
• PubChem Substance ID: 24899925
• UNSPSC Code: 41116107
• EC Number: 200-984-3
• MDL number: MFCD00057564

Properties

• drug control: USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada
• Quality Segment: 200
• solubility: ethanol: complete 50 mg/mL
• originator: Abbott
• SMILES string: CCCC(C)C1(CC)C(=O)NC(=S)NC1=O
• InChI: 1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
• InChI key: IUJDSEJGGMCXSG-UHFFFAOYSA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)

Description

Application

(±)-Thiopental was used to transiently anesthetize rats for in vivo NMR spectroscopy.[1]

Biochem/physiol Actions

Thiopental is an anesthetic that decreases cerebral metabolic rate without altering the blood flow or oxygen consumption.[2]

Features and Benefits

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves