X1129

Anti-XPC (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Xeroderma pigmentosum, complementary group C, Anti-XP3, Anti-XPCC
• MDL number: MFCD09265382
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 120 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): indirect immunofluorescence: 5-10 μg/mL using MCF7 cells fixed with paraformaldehyde-Triton; western blot: 0.5-1 μg/mL using MCF-7 cell lysates
• UniProt accession no.: Q01831
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... XPC(7508)

Description

General description

DNA damage recognition and repair factor, XPC complex subunit xeroderma pigmentosum group C (XPC) is a DNA damage recognition factor. The protein consists of 940 amino acids. The gene encoding XPC is localized on human chromosome 3p25.1 and consists of 18 exons.

XPC exists in vivo as a heterotrimeric complex with one of the two mammalian homologs of S. cerevisiae Rad23 (HR23A or HR23B) and centrin 2.

Immunogen

synthetic peptide corresponding to amino acids 922-940 of human XPC, conjugated to KLH via an N-terminal added cysteine residue.

Application

Anti-XPC (C-terminal) antibody produced in rabbit has been used in indirect immunofluorescence and western blotting

Biochem/physiol Actions

DNA damage recognition and repair factor, XPC complex subunit xeroderma pigmentosum group C (XPC) has a role in global genome nucleotide excision repair pathway. As part of the XPC complex, this protein binds to DNA sites having many lesions. Single nucleotide polymorphisms in the XPC gene have been linked to various cancers.

Defective XPC gene causes photosensitivity syndrome called xeroderma pigmentosum (XP), which is characterized by a very high incidence of light-induced skin cancer.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves