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Synthesis and free radical scavenging activity of some new spiropyranocoumarins.

Bioorganic & medicinal chemistry letters (2008-10-07)
Vassiliki Panteleon, Ioannis K Kostakis, Panagiotis Marakos, Nicole Pouli, Ioanna Andreadou
ZUSAMMENFASSUNG

A series of novel spiro-substituted 4-hydroxypyranocoumarins and their corresponding dihydropyrano cis-diols has been synthesized. Among them the spiroadamantylpyranocoumarin and the diols can interact with the stable free radical 1,1-diphenyl-2-picrylhydrazyl and scavenge superoxide anions generated in the xanthine-xanthine oxidase system.

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