1151855

Curcumin

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): (E,E)-1,7-Bis-(4-Hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dion, Diferuloylmethan, Natural Yellow 3
• Lineare Formel: [HOC₆H₃(OCH₃)CH=CHCO]₂CH₂
• CAS-Nummer: 458-37-7
• Molekulargewicht: 368.38
• Farbindexnummer: 75300
• Beilstein: 2306965
• MDL-Nummer: MFCD00008365
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329749465
• NACRES: NA.24

Eigenschaften

• Qualität: pharmaceutical primary standard
• Dampfdichte: 13 (vs air)
• API-Familie: curcumin
• Hersteller/Markenname: USP
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• SMILES String: COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
• InChI: 1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
• InChIKey: VFLDPWHFBUODDF-FCXRPNKRSA-N

Beschreibung

Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

• Evaluating the dose-dependent effects of curcumin nano-micelles on rumen fermentation, nitrogen metabolism, and nutrient digestibility in heat-stressed fattening lambs: This study investigates the application of high-purity curcumin in improving animal health and productivity under climate stress, highlighting its potential as a bioactive compound in veterinary nutritional research (Bokharaeian et al., 2024).


• Curcumin reduces myocardial ischemia-reperfusion injury, by increasing endogenous H2S levels and further modulating m6A: This research underscores curcumin′s bioactive role in cardiovascular protection, offering insights into its mechanism of action within cell signaling pathways related to heart health (Cui et al., 2024).


• Targeting CD8+ T cells with natural products for tumor therapy: Revealing insights into the mechanisms: This review discusses the therapeutic applications of curcumin in cancer treatment, focusing on its interaction with cellular mechanisms and its potential as a molecular marker in immunotherapy (Wang et al., 2024).


• Senolytic effects on dental pulp stem cell′s proliferation and differentiation during long-term expansion: This article examines curcumin′s potential to influence cell growth and repair processes, pertinent to its research applications in dental and regenerative medicine (Wang et al., 2024).


• Future aspects of plant derived bioactive metabolites as therapeutics to combat benign prostatic hyperplasia: This review highlights curcumin′s role as a leading natural compound in pharmacological research, focusing on its anti-inflammatory and neuroprotective properties for treating conditions like benign prostatic hyperplasia (Krishnamoorthi et al., 2024).

Biochem./physiol. Wirkung

Eine natürliche Phenolverbindung. Wirksames Antitumor-Mittel mit entzündungshemmenden und antioxidativen Eigenschaften. Curcumin wurde, zusätzlich zu seiner chemotherapeutischen Wirkung, als potenzielles chemopräventives Mittel beschrieben. Leitet die Apoptose in Krebszellen ein und hemmt die Phorbolester-induzierte Proteinkinase C (PKC)-Aktivität. Hemmt Berichten zufolge die Produktion von inflammatorischen Zytokinen durch Monozyten des peripheren Blutes und alveoläre Makrophagen. Wirksamer Inhibitor der EGFR-Tyrosinkinase und IκB-Kinase. Hemmt die induzierbare Stickoxidsynthase (iNOS), Cycloxygenase und Lipoxygenase. Dringt leicht in das Zytoplasma von Zellen ein, sammelt sich in membranösen Strukturen wie Plasmamembran, endoplasmatisches Retikulum und Kernhülle an.

Eine natürliche phenolische Verbindung, die für die gelbe Farbe von Kurkuma verantwortlich ist. Wirksames Anti-Tumor-Agens, mit Wirkung in unterschiedlichen Tumor-spezifischen Stoffwechselwegen. Antiphlogistikum und Antioxidans. Induziert Apoptose in Krebszellen und hemmt die Phorbolester-induzierte Proteinkinase C (PKC)-Aktivität. Es soll die Produktion von inflammatorischen Zytokinen durch Monozyten im peripheren Blut und Alveolarmakrophagen inhibieren. Wirksamer Inhibitor der EGFR-Tyrosinkinase und IκB Kinase. Hemmt induzierbare Stickstoffmonoxid-Synthase (iNOS), Cyclooxygenase (COX-2) und 5-Lipoxygenase (5-LOX).

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable