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Merck

59356-U

Supelco

Discovery® Cyano (5 µm) HPLC Columns

Discovery® Cyano HPLC Column

L × I.D. 15 cm × 4.6 mm, HPLC Column

Synonym(e):

Cyano-gebundene Phasensäule

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Produktbezeichnung

Discovery® Cyano HPLC-Säule, 5 μm particle size, L × I.D. 15 cm × 4.6 mm

Materialien

stainless steel column

Qualitätsniveau

Agentur

suitable for USP L10

Produktlinie

Discovery®

Leistungsmerkmale

endcapped

Hersteller/Markenname

Discovery®

Verpackung

1 ea of

Kennzeichnungsgrad

4.5% Carbon loading

Parameter

≤70 °C temp. range
400 bar pressure (5801 psi)

Methode(n)

HPLC: suitable
LC/MS: suitable

L × ID

15 cm × 4.6 mm

Oberflächenbereich

200 m2/g

Oberflächendeckung

3.5 μmol/m2

Verunreinigungen

<10 ppm metals

Matrix

silica gel, high purity, spherical base material
fully porous particle

Aktive Matrixgruppe

cyano phase

Partikelgröße

5 μm

Porengröße

180 Å

pH Betriebsbereich

2-8

Anwendung(en)

food and beverages

Trenntechnik

hydrophilic interaction (HILIC)
normal phase
reversed phase

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Allgemeine Beschreibung

Die Discovery® Cyano HPLC-Säule wird für die Retention und Abscheidung von stark basischen Analyten, einschließlich quaternären Ammoniumsalzen, mit ausgezeichneten Peak-Formen verwendet.

Leistungsmerkmale und Vorteile

  • Geringe Hydrophobie für eine schnelle Elution von hydrophoben Analyten
  • Ausgezeichnete Peak-Form und Retention von stark basischen Analyten
  • Retention von polaren Analyten
  • Einzigartige Selektivität
  • Signifikant weniger Retention als C18 (erfordert in der Regel weniger % organischer mobiler Phase)
  • Stabile, gering blutende LC/MS-Trennungen
  • Kompatibel mit stark wässrigen organischen Phasen

Rechtliche Hinweise

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

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Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

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E F Nemeth et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at
S L Able et al.
British journal of pharmacology, 162(2), 405-414 (2010-09-16)
The P2X7 receptor is implicated in inflammation and pain and is therefore a potential target for therapeutic intervention. Here, the development of a native tissue radioligand binding, localization and ex vivo occupancy assay for centrally penetrant P2X7 receptor antagonists is
Thomas J Woltering et al.
Bioorganic & medicinal chemistry letters, 18(3), 1091-1095 (2007-12-22)
A series of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Replacement of a cyano group by a five-membered heterocycle produced compounds inhibiting the binding of [(3)H]-LY354740 to rat mGluR2 with low nanomolar affinity and consistent functional effect at both
Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
Aaron D Milstein et al.
Trends in pharmacological sciences, 29(7), 333-339 (2008-06-03)
Presynaptic glutamate release elicits brief waves of membrane depolarization in neurons by activating AMPA receptors. Depending on its precise size and shape, current through AMPA receptors gates downstream processes like NMDA receptor activation and action potential generation. Over a decade

Fragen

1-4 von 4 Fragen  
  1. ¿Me podrías confirmar que la composición de esta columna es end-capped cyanosilyl silica gel for chromatography R? Gracias!

    1 Antwort
    1. These columns are end-capped, but the phase is cyanopropyl.

      Hilfreich?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 Antwort
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Hilfreich?

  3. How can I determine the shelf life / expiration / retest date of this product?

    1 Antwort
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Hilfreich?

  4. Please provide the below details for the column Carbon loading%- Pore size- Surface area- pH stability- End capping-

    1 Antwort
    1. TS Answer:
      - 4.5% Carbon loading
      - Pore size: 180 Å
      - Surface area: 200 m2/g
      - Operating pH range: 2-8
      - Endcapped
      - Particle Size: 5 μm
      - Temperature Range: ≤70 °C
      - Maximum Pressure: 400 bar pressure (5801 psi)
      - Suitable for USP L10

      Hilfreich?

Bewertungen

Aktive Filter

  1. India
    • Bewertung 1
    • Stimmen 0
    2 von 5 Sternen.

    Column to column variation

    Variation in Retention time from column to column observed

    Mit Google übersetzen

    Hilfreich?

    1. Antwort von Sigma-Aldrich Corporation:

      Thank you for your review. While minor variability between batches may occur, the degree of difference in retention times would be impacted by run times. Assuming all other conditions are identical, an overall +/- 5% may be possible. As there are a number of variables to consider, we encourage customers who experience problems with our products to call or email us for additional technical support. Please visit https://www.sigmaaldrich.com/US/en/support/customer-support to submit a Product Technical Inquiry.

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