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Supelco

Discovery® Cyano (5 µm) HPLC Columns

L × I.D. 10 cm × 3 mm, HPLC Column

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About This Item

UNSPSC-Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52

product name

Discovery® Cyano HPLC-Säule, 5 μm particle size, L × I.D. 10 cm × 3 mm

Materialien

stainless steel column

Agentur

suitable for USP L10

Produktlinie

Discovery®

Leistungsmerkmale

endcapped

Hersteller/Markenname

Discovery®

Verpackung

1 ea of

Kennzeichnungsgrad

4.5% Carbon loading

Parameter

≤70 °C temp. range
400 bar pressure (5801 psi)

Methode(n)

HPLC: suitable
LC/MS: suitable

L × ID

10 cm × 3 mm

Oberflächenbereich

200 m2/g

Oberflächendeckung

3.5 μmol/m2

Verunreinigungen

<10 ppm metals

Matrix

silica gel, high purity, spherical base material
fully porous particle

Aktive Matrixgruppe

cyano phase

Partikelgröße

5 μm

Porengröße

180 Å

operating pH range

2-8

Anwendung(en)

food and beverages

Trenntechnik

hydrophilic interaction (HILIC)
normal phase
reversed phase

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Leistungsmerkmale und Vorteile

  • Geringe Hydrophobie für eine schnelle Elution von hydrophoben Analyten
  • Ausgezeichnete Peak-Form und Retention von stark basischen Analyten
  • Retention von polaren Analyten
  • Einzigartige Selektivität
  • Signifikant weniger Retention als C18 (erfordert in der Regel weniger % organischer mobiler Phase)
  • Stabile, gering blutende LC/MS-Trennungen
  • Kompatibel mit stark wässrigen organischen Phasen

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Rechtliche Hinweise

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

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Analysenzertifikate (COA)

Lot/Batch Number
283703-01
269219-01
158453-01
153563-02
153563-01

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E F Nemeth et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at
Aaron D Milstein et al.
Trends in pharmacological sciences, 29(7), 333-339 (2008-06-03)
Presynaptic glutamate release elicits brief waves of membrane depolarization in neurons by activating AMPA receptors. Depending on its precise size and shape, current through AMPA receptors gates downstream processes like NMDA receptor activation and action potential generation. Over a decade
Aleem Gangjee et al.
Journal of medicinal chemistry, 53(22), 8116-8128 (2010-10-27)
Two classes of molecules were designed and synthesized based on a 6-CH(3) cyclopenta[d]pyrimidine scaffold and a pyrrolo[2,3-d]pyrimidine scaffold. The pyrrolo[2,3-d]pyrimidines were synthesized by reacting ethyl 2-cyano-4,4-diethoxybutanoate and acetamidine, which in turn was chlorinated and reacted with the appropriate anilines to
Xuqing Zhang et al.
Journal of medicinal chemistry, 50(16), 3857-3869 (2007-07-20)
A novel series of pyrazolines 2 have been designed, synthesized, and evaluated by in vivo screening as tissue-selective androgen receptor modulators (SARMs). Structure-activity relationships (SAR) were investigated at the R1 to R6 positions as well as the core pyrazoline ring
Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
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