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54127-U

Supelco

2-(2-Pyridyl)ethyl Silica Gel

bed wt 100 mg, volume 1 mL, pk of 108

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About This Item

UNSPSC-Code:
41115712
NACRES:
NB.21

Zusammensetzung

bed wt, 100 mg

Verpackung

pk of 108

Methode(n)

solid phase extraction (SPE): suitable

Volumen

1 mL

Aktive Matrixgruppe

WAX phase

Anwendung(en)

food and beverages

Trenntechnik

ion exchange

Allgemeine Beschreibung

Retention Mechanism: Anion-exchange
Sample Matrix Compatibility: Organic or aqueous Solutions

  • Weak anion exchanger ideal for extracting strong basic compounds that remain charged at all pH levels
  • Unlike conventional weak anion exchange SPE phases such as -NH2 (aminopropyl) that have a pKa of 9-10, a pH ≤ 7 is required to protonate or ionize the stationary phase to facilitate analyte retention. Elution is typically done by increasing the pH to 11 resulting in neutralization of the SPE phase.
  • 2-(2-pyridyl)-ethyl silica gel has a pKa of ~6. Therefore, analyte elution is feasible at a pH ≥ 7. This characteristic is important for extracting analytes that are not stable (e.g. hydrolyzes) at high pHs typically required for elution when using traditional weak anion exchangers.
  • Ideal for extracting acyl-coenzyme A esters from tissue.
  • For more information, please see: Minkler, P.E., Kerner, J., Ingalls, S.T., Hoppel, C.L., Novel isolation procedure for short-, medium-, and long-chain acyl-coenzyme A esters from tissue, Analytical Biochemistry 376 (2008) 275–276

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Andrea Arias-Alvarado et al.
Analytical biochemistry, 615, 114067-114067 (2020-12-20)
Cellular availability of acetyl-CoA, a central intermediate of metabolism, regulates histone acetylation. The impact of a high-fat diet (HFD) on the turnover rates of acetyl-CoA and acetylated histones is unknown. We developed a method for simultaneous measurement of acetyl-CoA and

Artikel

Solid Phase Extraction: Ion Exchange Methodology

SPE retention mechanism in this case is based on the electrostatic attraction of charged functional groups of the analyte(s) to oppositely charged functional groups on the sorbent.

Protokolle

Solid Phase Extraction: Normal Phase Methodology

Normal-phase SPE separates analytes based on polar interaction with sorbents in diverse sample matrices.

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